Technical University of Denmark (DTU)

Postdoc in Strain Engineering

Technical University of Denmark (DTU)

2800 Kgs. Lyngby, Denmark

The Synthetic Biology Tools for Yeast section at the Novo Nordisk Foundation Center for Biosustainability (CfB), at the Technical University of Denmark (DTU) is seeking talented postdocs in strain engineering to work on the development of yeast cell factories for production of bioactive natural products. The project is part of an international collaboration (see also https://www.miami-project.eu/) focused on plant biosynthetic pathway discovery, refactoring pathways into microbial cells using advanced synthetic biology techniques, predictive pathway modeling, and bioactivity testing of new human therapeutics.

The competences in the laboratory, led by Senior researcher Michael Krogh Jensen, are focused on the development of synthetic biology tools for advanced genome engineering and high-throughput screening systems to advance the field of cell factory engineering. To further advance the development of new microbial supply chains for plant-derived human therapies new strain engineers (postdoc) are needed.

Responsibilities and tasks
As a strain engineer (postdoc) in the Synthetic Biology Tools for Yeast section at CfB, you’ll work closely with a team of scientists to support, expand, and implement our core synthetic biology tools for refactoring of plant biosynthetic pathways for human therapeutics in yeast, and to apply data-driven strategies for further cell factory optimization. To strengthen our team’s strain engineering and data analysis pipeline, and further advance our visions for delivery of new supply chains for bioactive natural products, the main responsibilities of the candidate will include:

  • Design biosynthetic pathways for human therapeutics in yeast
  • Apply state-of-the-art genome engineering technologies to efficiently refactor biosynthetic pathways in yeast
  • Cultivation of engineered yeast, perform metabolite profiles, and analyze MS-based data
  • Multi-variate data analysis
  • Disseminate results to team and publish research results

Qualifications
The ideal candidate will have:
  • PhD in relevant areas within biochemistry, bioengineering, molecular microbiology, synthetic or systems biology
  • Strong academic trach record, including projects on microbial strain engineering
  • High motivation to achieve team goals and dedication to work
  • Demonstrated ability to adapt to a dynamic work environment and perform collaborative research

Preference will be given to the following detailed skills/experience:
  • Experience in molecular biology techniques and handling microbial cell cultures
  • Multi-variate data analysis (e.g. phenotype, metabolites, genomics data)
  • Basic knowledge in analytical chemistry, with experience in MS sample preparation and data analysis
  • Knowledge in protein sequence analysis and homology-modelling
  • Proven track-record of data management skills
  • Strong oral and written skills in English
  • Proactive attitude and eager to trouble-shoot, responsibility, team spirit, and excellent collaboration skills.

We offer
  • An exciting, collaborative, and entrepreneurial team focusing on research and innovation with both societal and environmental impacts.
  • A well-resourced laboratory with a friendly work environment
  • An excellent and hard-working team of pathway discoverers, data scientists, and strain engineers with efficient knowledge-transfer for you to learn and thrive in.

Further information
Further information may be obtained from Senior researcher Michael Krogh Jensen (mije@biosustain.dtu.dk or +45 61284550).

You can read more about DTU Biosustain at www.biosustain.dtu.dk

Application procedure
Please submit your online application no later than 20 December 2019.

To view the full announcement and to apply: www.career.dtu.dk

Please apply via recruiter’s website.

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