The Laboratory of Intestinal Neuro-Immune Interaction, part of the Translational Research Center for Gastrointestinal Disorders (TARGID) of KU Leuven, offers a postdoc position for a scientist with expertise in mucosal immunology.
TARGID aims to provide insight in physiological and pathophysiological mechanisms in order to identify new targets ultimately leading to better therapies for gastrointestinal disorders such as functional and inflammatory bowel diseases. To this end, pre-clinical and clinical expertise is combined with state of the art technology to provide top quality research and to create a stimulating setting for bidirectional interaction between basic and clinical researchers. This approach allows fast translation of discoveries from bench to bedside with improvement of patient care as ultimate goal.
TARGID is an internationally recognized research center that also aspires to provide multidisciplinary education in a challenging and exciting scientific environment. TARGID is part of diverse national and international networks allowing exchange of expertise further contributing to excellent education of young and talented researchers.
Our research group focuses on the role of mucosal immune activation (in particular focusing on B cells, plasma cells and mast cells) in the intestine as key mechanism of altered pain perception in functional gastrointestinal disorders. Our group recently demonstrated mast cell activation as a major mechanism leading to sensitisation of nociceptors and abnormal pain perception in both preclinical models and patients. These findings have led to the introduction of histamine 1 receptor antagonists as novel treatment for this disorder. The present project aims to unravel the mechanisms leading to mast cell activation (IgE cross-linking, MRGX2).
Applicants should have completed a PhD in mucosal immunology. They should have extensive experience with immune cell isolation from intestinal tissue, FACS and cell sorting and molecular biology.
Full applications including curriculum vitae, list of publications and 2 references should be sent to Prof.dr. G.Boeckxstaens(Guy.Boeckstaens@med.kuleuven.be), before January 1st 2020.
- You will be responsible to design study protocols and perform experiments
- You will be supervising PhD students involved in the project
- You will collaborate with other members of the research group
- You will be responsible for reporting and publishing the obtained results
- You are an experienced molecular biologists / biochemist / bioengineer with a PhD in mucosal immunology
- You have expertise in isolation and characterization of immune cells (especially mast cells, B cells, plasma cells) from intestinal tissue (lamina propria, MLN, preferentially also from human intestine) and spleen
- You have experience in supervising students
- You have experience writing research papers
- You are capable of writing grants and obtaining research funding, and are willing to apply for a postdoctoral fellowship of the Flemish government (FWO)
- We offer you a post-doc position for one year, with the opportunity for renewal until 3-5 years. You are stimulated to apply for a postdoctoral fellowship of FWO (see above).
For more information please contact Prof. dr. Guy Boeckxstaens, tel.: +32 16 33 02 37, mail: firstname.lastname@example.org.
You can apply for this job no later than January 01, 2020 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.