The University Hospital Heidelberg (UKHD) is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
Postdoc in Immunology / Nucleic Acid Immunity (m/f/d)
searched for the Institute for Immunology, Roers Lab.
- Job-ID: V000010655
- Field of application: Institute for Immunology
- Location: Heidelberg
- Start date: 01.03.2023
- Job Category: Science and teaching
- Working hours: full-time
- Limitation: Temporary (initially limited to 3 years with the option of extension)
- Contract: TV-L
We investigate pathogenetic principles in autoimmune diseases caused by aberrant activation of nucleic acid sensors. Innate immune detection of viral infection relies on sensing of viral DNA or RNA by specialized pattern recognition receptors that trigger antiviral type I IFN and NF-kB responses. While acute activation of antiviral immunity is essential for defense, chronic activation of the same pathways can cause a breakdown of T and B cell self-tolerance and lead to devastating autoimmunity, as for example in Systemic Lupus and many related conditions. In the setting of Collaborative Research Center 237, we address molecular mechanisms of inappropriate activation and regulation of innate antiviral immunity using cell culture, mouse models and human samples. Spontaneous activation of nucleic acid sensors by endogenous DNA or RNA is also relevant in tumor cells and is emerging as an important determinant of anti-tumor immunity.
A successful candidate will use
- genetic engineering (CRISPR, recombineering)
- mouse genetics, conditional gene targeting
- single cell RNA sequencing
- cell culture
- flow cytometry
We are looking for a dedicated and enthusiastic PhD or MD experienced in CRISPR-mediated genome engineering. We appreciate experience in writing scientific publications and expect motivation to work independently and to develop a research field.
- A vibrant international research environment
- A comprehensive spectrum of key technology
- Collaborative work in a friendly team
- Flexible working hours
- Target-oriented individual further education and training opportunities
- Targeted training on the job
- Ticket for public transport
- Subsidy for holiday care for school children
- Active health promotion
- Company pension scheme
- Access to the university library and other university facilities (e.g. university sports)
Contact & Application
For any questions please contact Professor Axel Roers by phone or email.
We are looking forward for your application by email. Applicants should submit a full CV, list of publications and a motivation letter including a description of previous research experience, a summary of the PhD thesis, certificates and recommendation letters or contact details of referees.
Institut für Immunologie
Prof. Axel Roers, Director
Im Neuenheimer Feld 305
phone: +49 6221 56-4001