Institute of Computational Biology
Area of research:
Scientific / postdoctoral posts
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The Institute of Computational Biology is a globally recognized department for innovations anchored at the Helmholtz Zentrum Munich and the Technical University of Munich.
We are looking for a post-doctoral fellow hired as part of the transregio SFB TR84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia” on the C1 Project: “RNA-mediated regulatory networks in Legionella pneumophila pneumonia”.
She/he will focus on studying the complex network of coding RNAs, non-coding RNAs and RNA Binding Proteins (RBPs) that regulate lung infection processes from high-throughput multi-omics data. The fellow will develop innovative computational approaches to exploit the potential of already generated high-throughput experiments in order to identify deregulated transcripts, alternative splicing events and other post-transcriptional regulatory events triggered by bacterial infections. The potential of newly identified coding and non-coding RNAs as diagnostic and prognostic clinical biomarkers in pneumonia, and targets for in vivo applicable RNA-inhibitors, will be tested experimentally in collaboration with the group of Prof. Bernd Schmeck at the University Clinic of Marburg.
Post-doc in „Development of Computational Methods for Multi-Omics data and RNA Biology“
Set up of an NGS computational pipeline, integrated by bioinformatics network analysis, to identify crucial bacterial and human factors important for pathogenicity and modulation of the immune response; integration of RNA-seq, ChIP-seq and proteomics dataPattern recognition and functional analysis of non-coding RNAs and RBPsApplication of machine learning methods to the prediction of new post-transcriptional regulators of the lung infection process
Ph.D. in Bioinformatics, Biostatistics, Physics or equivalent with interest in RNA Biology, Microbiology and disease modeling. Alternatively a Ph.D. in Biotechnology, Biology or equivalent with significant and documented experience in Bioinformatics.Excellent programming skills in R, Python and/or C/C++Excellent academic recordKeen interest in RNA Biology and post-transcriptional regulationExperience with NGS data analysis and machine learning or multivariate statistics methodsScientific curiosity, propensity to problem solving, ability to work independently and develop original ideasHighly motivated to work in a multi-disciplinary environment and in collaborations with experimental and medical partnersExcellent communication and presentation skills, including experience in communicating across discipline boundariesFluency in spoken and written English
The following skills are considered advantageous
Previous projects in non-coding RNA biology (e.g. microRNAs, long non-coding RNAs) and/or ImmunologyKnowledge of network analysis, as well as graph-clustering techniquesKnowledge of basic RNA bioinformatics algorithms for the analysis of RNA structures and functionsWorking in a Linux environment, with experience of shell scripting, cluster or cloud computing
At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.
Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund).
The position is (initially) limited to three years.
The activity involves special knowledge and experience specific to own scientific skills.
As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.
We are looking forward to receiving your comprehensive online application (cover letter, a short summary of your present and future research interests, CV with a list of publications, scans of your master and PhD certificates, contact details of 3 referees) as a single PDF document until April 07, 2019.