Postdoc in Molecular Neuroscience; Gothenburg, Sweden (up to 2 positions)
We are interested in understanding – on a molecular level – how synaptic connections between neurons are formed and how impairments in synaptic functions may contribute to human disease. To address these fundamental questions, we combine mouse genetics and gene-edited human neurons with functional assays and protein biochemistry and proteomics.
Our recently started research group is well funded by support from the Swedish Research Council (Vetenskapsrådet) and by being part of the Wallenberg Centre for Molecular and Translational Medicine (http://wcmtm.gu.se). The lab belongs to the University of Gothenburg’s Institute for Biomedicine but is physically located at the well-equipped research laboratories of the Sahlgrenska University Hospital (Department of Clinical Chemistry).
The position(s) will provide the applicant opportunities to engage in one of the following projects:
(1) Study the in vivo role of two genes believed to play a role in shaping the molecular composition of specific synapses by analyzing a (yet unpublished) knockout mouse models available in the lab.
(2) Generate and study disease mechanisms of monogenic, neurodevelopmental disease that results from genetic variants identified in the clinic and predicted to impair synaptic function. Embryonic stem cells (ESCs) or induced pluripotent cells (iPSCs) gene-edited by CRISPR/Cas9 and adeno-associated virus (AAV) will be differentiated into human neurons for assessment of cellular phenotype(s).
(3) Study mechanisms of synapse formation, with particular focus on the role of glycosaminoglycan (GAG) chains and their composition. Several proteins involved in the assembly and function of synapses are proteoglycans, but it remains largely unknown to what extent the carbohydrate chains and their composition contribute to synaptic diversity and specificity. Their role will be addressed using a combination of protein biochemistry, mass spectrometry, and experimental genetics in a reductionist system for synapse formation.
We invite applications from enthusiastic and motivated individuals with a PhD in a relevant field. Applicants preferably have a strong background in molecular biology and/or neuroscience. Experience in experimental techniques relevant for the project is advantageous but not an absolute requirement.
Capacity for analytical thinking and problem solving as well as good documentation skills and proficiency in both spoken and written English are required. The candidate(s) should be willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating applicants.
The application should submit the following documents in English:
• Personal letter explaining your motivation for applying for the position (max 1 page)
• Curriculum vitae (max 2 pages)
• List of publications
• Contact information of at least two references
The position is for two (1+1) years, with possibility of further extension.
Please submit your interest in this position or any questions about the opportunity to firstname.lastname@example.org