The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Division of Signal Transduction and Growth Control is seeking a
Chronic inflammation is a main driver of the development of hepatocellular carcinoma (HCC), one of the most frequent and dismal human malignancies. Employing mouse models of inflammation-driven cancer including squamous cell carcinoma and HCC, our Division has identified the receptor RAGE and its ligands, the damage molecular pattern (DAMP) www.livercancer.demolecules S100A8/A9 and HMGB1 as important players of chronic inflammation and cancer development. (Hummerich et al., 2006, Oncogene 25:111-21; Gebhardt et al., 2008, J Exp Med 205:275-85; Nemeth et al., 2009, Hepatology 50:1251-62; Wiechert et al., 2012, Cell Comm Signal, 10:40; Pusterla et al., 2013, Hepatology, 58:363-73).
The current project aims at analysing the function of the receptor RAGE in liver progenitor cells during acute and chronic liver damage, hepatitis and deveopment and progrssion of liver cancer. The candidate will apply gain-of-function and loss-of-function approaches in genetically modified mice and in vitro cell cultures to define the role of these molecules in chronic liver damage, inflammation, tumor cell formation and invasion using state-of-the-art transgenic and global gene expression technologies. This project is part of the DFG funded research consortium TR-209 “Liver cancer” (www.livercancer.de).
We are looking for a highly motivated and ambitious postdoc with a Ph.D. to complement our team. The candidate should have a strong background in molecular and cellular biology demonstrated by peer-reviewed publications and a strong interest in liver tumor biology. Excellent experimental and analytical skills in advanced cell culture techniques and mouse genetics including animal experimentation are mandatory.
The position is limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
For further information please contact
Prof. Dr. Peter Angel, phone +49 6221 42-4570.
The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
To apply for a position please use our online application portal (www.dkfz.de).
We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.