Postdoc for Research project "Experimental Systems Biology of Lung Regeneration and Fibrosis" (f/m/d)

Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU)

München, Germany

Work group:

Institute of Lung Biology

Area of research:

Scientific / postdoctoral posts

Starting date:


Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

A postdoctoral research position is available from March 2019 in the Schiller lab (Institute of Lung Biology and Disease) at Helmholtz Zentrum München. The full-time position is fully funded for a duration of two years with the possibility of extension. Transnational mobility and application for a postdoctoral fellowship (Marie Curie, Embo, etc) is most welcome.

We are looking for highly motivated individuals ideally with a strong background in biology. Previous experience with systems biology approaches is expected. Experience with lung biology and disease and animal models thereof is a big advantage. Possible projects include establishment of single cell and nuclei multi-omics analysis of mouse models of disease and human lungs and functional analysis of newly discovered cell states in mouse lung (mouse genetics, lineage tracing, imaging). The data analysis part will include application of state of the art analytical tools for scRNAseq data in close collaboration with the Institute of Computational Biology at HMGU (Theis lab).

The Schiller lab is using systems biology tools, such as mass spectrometry driven proteomics and single cell transcriptomics, in combination with mouse models of lung disease and human patient samples, to identify fundamental molecular principles of lung regeneration and fibrosis. Dr. Schiller has a longstanding interest in cell adhesion and extracellular matrix (ECM) biology and developed state of the art mass spectrometry methodology for in depth characterization of cell-matrix adhesions and ECM in health and disease. Combining proteomics and single cell transcriptomics, the Schiller lab (in collaboration with the Theis lab) recently charted the molecular and cellular changes in the aging mouse lung at single cell resolution, discovering aging hallmarks and predicting the cellular sources of regulated proteins (Angelidis et al, Nature Communications 2019).

At the next possible time the ILBD is looking for a

Postdoc for Research project "Experimental Systems Biology of Lung Regeneration and Fibrosis" (f/m/d)

Your Responsibilities

Single cell transcriptomics analysis of mouse models of lung disease and human lungsAnimal experiments (bleomycin injury model, Cre-ERT models for lineage tracing and cell type depletion)Histology, immunfluorescence and confocal and light sheet microscopy

 Your Qualifications

PhD degree in biology or related areaExperience with systems biology approaches and ideally with single cell biologyPrevious experience with mouse workPassion for science and scientific workProficient in written and spoken EnglishBeing comfortable in interacting with colleagues in an interdisciplinary setting

Our Offer

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

Remuneration and benefits are in accordance with the collective agreement for the public service (TV EntgO Bund).

The position is (initially) limited to two years.

The activity involves special knowledge and experience specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

We are looking forward to receiving your comprehensive online application.

Please apply via recruiter’s website.

Quote Reference: 2018/0566