University of Pennsylvania (PENN)

Postdoc fellow - CRISPR screens in hematopoietic stem cells to study DNA repair and DNA replication

University of Pennsylvania (PENN)

Philadelphia, PA, United States

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong’s laboratory studies cytokine receptor signaling in replication stress, DNA repair, and ubiquitin signaling in hematopoietic stem cells, bone marrow failure, and leukemia. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to leukemia or cancer in general. Genome integrity plays a critical role in blood development and the prevention of leukemia and ageing. This postdoctoral fellow position will focus on studying the mechanisms that safeguard the genome during DNA replication and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. CRISPR screens with our expert collaborators will delineate a new understanding of stem cell fitness upon replication stress and point to potentially druggable pathways for intervention in the treatment of diseases with stem cell dysregulation.

 

Our recent publications include: Cell Stem Cell, 2021 Jul 1;28(7):1275-1290; Blood 2021 Dec 2;138(22):2244-2255; Nature communications 9(1): 3915, Sep 2018; Genes & development 31(10): 1007-1023, May 2017; Blood 133(14): 1560-1571, Apr 2019. You can find more of our recent publication and laboratory information in below website.

 

https://www.med.upenn.edu/apps/faculty/index.php/g275/p8146029

 

Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, as well as mouse models.

 

Highly motivated candidates with publication records are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to:

 

tongw@chop.edu

 

Wei Tong, Ph.D

Professor and Distinguished Chair in Pediatrics,

Children’s Hospital of Philadelphia,

University of Pennsylvania School of Medicine,

Co-Director, Hematopoietic Stem Cell program, 

Institute for Regenerative Medicine at UPENN

Abramson Bldg. 310D,

3615 Civic Center Blvd.,

Philadelphia, PA 19104

Tel: 267-426-0930

 

Key words:

stem cells, leukemia, signaling, cytokine receptor, kinase, ubiquitination, genome integrity, DNA repair, replication, CRISPR

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Position

Postdoc fellow - CRISPR screens in hematopoietic stem cells to study DNA repair and DNA replication