ER-C-3 – Strukturbiologie
Area of research:
Scientific / postdoctoral posts
The Ernst Ruska-Centre (ER-C) at the Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. The scientific research topics range from condensed matter physics to cryo-EM on biomacromolecules as well as future developments of electron microscopy. The ER-C currently has a total of 13 electron microscopes including the PICO FEI Titan with a point resolution of 0.5 Å and several state-of-the-art cryo-microscopes such as an FEI Talos Arctica including Bioquantum K3 and an FEI Talos 120. In addition, we have access to cryo-FIB/SEM instrumentation and a cryo-confocal light microscope enabling us to use a cryo-CLEM workflow to study sub-cellular structures using cryo-tomography. Upon launch of the ERC2.0 project, unique world-wide leading equipment including sample preparation and high-end electron microscopes will be installed in the near future.
- Cryo-EM sample preparation and optimization for single-particle EM and/or cryo-FIB/SEM followed by electron tomography
- Training of in-house and external users on data collection, evaluation and image processing of data for structural biology projects on various cryo-electron microscopes
- Development of novel sample preparation workflows tailored to advancing cryo-EM projects for high-resolution cryo-EM structure determination and/or cellular tomography
- Application of new approaches to challenging structural cell biology projects at the ER-C3
- A master`s degree in natural sciences with subsequent doctorate degree
- Several years of hands-on experience in cryo-electron microscopy
- Track record in single-particle cryo-EM structure determination and/or cellular tomography
- Experience with sample preparation and microscopy hardware so that (s)he can help other users and establish new routines in sample preparation and data acquisition
- Outstanding supercomputing facilities suitable for cryo-EM image processing
- A multi-disciplinary team with various scientific backgrounds
- An excellent track record at the ER-C 3 in the investigation of the structural and molecular mechanism of autophagy and high-resolution structure determination.
- A vibrant electron microscopy community on our campus in Jülich, as well as a many other well-equipped biophysics and structural biology laboratories.
- Exciting working environment on an attractive research campus with excellent infrastructure, located between the cities of Cologne, Düsseldorf, and Aachen
- A comprehensive further training programme
- Flexible working hours and various opportunities to reconcile work and private life
- Limited for 2 years with possible longer-term prospects
- Full-time position with the option of slightly reduced working hours
- Salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD)
Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations.We also welcome applications from disabled persons.