Giessen University (JLU)

Postdoc and PhD Position On The Microenvironmental and Metabolic Control Of Cancer Cell Plasticity

Giessen University (JLU)

Gießen, Germany

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for

1 POSTDOC AND 1 PHD POSITION:
MICROENVIRONMENTAL AND METABOLIC CONTROL OF CANCER CELL PLASTICITY

in the field of tumor biology/neurooncology. The positions are available immediately.

Your profile:
Postdoc:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong track record and research background in molecular and cell biology. Experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: hypoxic signalling, functional genomics or other high-throughput screening methods, epigenetics or in vivo tumor (brain) metastasis models, advanced microscopy methods, analysis of signalling pathways, proteomic analysis including analysis of posttranslational modifications, protein biochemistry.
Duration of the position: 3 years, with the possibility of extension

PhD student:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain an MSc degree, diploma or equivalent. The applicants should possess a strong interest in cancer research, molecular and cell biology, the ability to integrate in an international team, learn about new fields and establish new experimental techniques. Prior experience with laboratory mouse, cell culture, or tumor biology related assays will be an advantage.
Duration of the position: 3 years, with the possibility of extension

Topic:
Regions of low oxygen tension are common findings in malignant tumors, being associated with increased frequency of tumor invasion and metastasis, and thus critically determining the clinical behaviour and outcome of tumors. We work on a broad range of topics, primarily related to the functions of members of the 2-oxoglutarate dependent dioxygenases including the control of oxygen sensing pathways by PHDs, their regulators and downstream effectors such as HIFs – in diverse aspects of cancer biology. We are particularly interested in understanding how stress signals from the tumor microenvironment are sensed and integrated to reprogram the metabolic and epigenetic state of the cell in order to promote tumor progression and therapy resistance. The proposed projects will aim to 1) dissect the role of the tumor microenvironment in brain tumors and metastasis with emphasis on the crosstalk of the oxygen sensing pathway with other cellular signalling pathways, including Notch and EGFR and tumor metabolism and 2) understand the role of the hypoxic tumor microenvironment in the epigenetic control of tumor growth by dissecting the interplay between HIFs and histone methylation.

What we offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities including the PhD graduate program of the International Giessen Graduate school for Life Sciences (GGL http://www.uni-giessen.de/cms/fbz/zentren/ggl) with the possibility to work on cutting edge research projects. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, miRNA analyses, DNA methylation array analysis, next generation sequencing, chromatin immunoprecipitation, bioinformatic analysis, animal models and in vivo tumor models as well as tumor biopsies.

Application:
Please send your application as a single PDF: cover letter, your CV, certificates of your qualifications, your publication list, recommendation letters from at least two referees and their contact details until 31.03.2020 to Dr. Attila Németh (Attila.Nemeth at patho.med.uni-giessen.de)

Applicants with disabilities but otherwise equal qualifications will be preferred.

Selected references:
Dopeso et al, Cancer Research 2018;78(7):1805-1819.
Depner et al, Nat Commun. 2016;7:12329.
Filatova et al, Cancer Research 2016;76(19):5845-5856.
Henze et al, Nat Commun. 2014;5:5582.
Garvalov et al, Nat Commun. 2014;5:5577.
Sawamiphak et al, Nature 2010; 465(7297):487-91

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB
Position

Postdoc and PhD Position On The Microenvironmental and Metabolic Control Of Cancer Cell Plasticity