The research group of Prof. Mahlapuu is seeking a highly motivated and talented post-doctoral fellow for studies of molecular pathogenesis underlying type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) with the long-term goal of finding new treatment strategies. The successful applicant will have a key role in a project team that is in the front line of metabolic research in lipid partitioning and insulin sensitivity. The project is translational including studies in human cell lines, unique mouse models, and well-characterized patient cohorts.
Project description: The candidate will study the molecular mechanisms controlling lipid partitioning and insulin sensitivity in peripheral tissues prone to diabetic damage, with the focus on new key mediators – STE-type protein kinases. The candidate will apply state-of-the-art analysis tools in human biopsies; however, the main focus of the project will be on in vivo studies in mouse models and in vitro functional assays in human cultured cells, where gene functions will be modified genetically or by pharmacological agonists/antagonists. The research group of Prof. Mahlapuu is part of a large network of diabetes researchers at the University of Gothenburg, Sweden and has excellent experimental infrastructure as well as extensive international collaborations.
Scholarship period: The scholarship covers a period of 12 months with possibility of prolongation up to a maximum of 24 months in total.
Preliminary start date: 1st Nov 2020
Qualifications: The eligible applicant must hold a PhD degree within a relevant field obtained not later than 3 years estimated from 8 August 2020, and is expected to have a strong record of scientific productivity with publications as first or last author in international peer reviewed journals. The applicant must not have been employed at University of Gothenburg in the past two years. The applicant must have extensive experimental background in in vivo studies in mice as well as experience in cell culture. Previous research experience in type 2 diabetes and/or fatty liver disease is beneficial. The successful applicant is expected to plan, execute, and analyze experiments in an independent manner and to contribute scientifically to the group. Candidates must have excellent oral and written communication skills in English and good knowledge of statistical analysis methods.
Written application, including reference number, is to be sent via e-mail to Prof. Mahlpauu and must include the following: • CV • Personal letter stating the reasons why the study suits the applicant (maximum one page) • List of publications including the SCI of the journals • References (2) • Application deadline: 8 Aug 2020
Information regarding scholarships: • Scholarships do not give rise to sickness benefits, compensation from the Social Insurance Office or retirement pension. • The scholarship sum is paid out quarterly • Scholarships are tax-exempt • A scholarship holder cannot be hired after the scholarship period due to tax reasons.
Supervisor/contact person: Margit Mahlapuu, Prof. in Molecular Genetics at the Dept. of Chemistry and Molecular Biology, Co-director Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg PO Box 462 SE405 30 Gothenburg, Sweden Tel: +46 706 310109; Email: Margit.Mahlapuu@gu.se