The Ohio State University (OSU)

Post Doctoral Scholar

The Ohio State University (OSU)

Columbus, OH, AK, United States

The Ohio State University Wexner Medical Center in Columbus, Ohio is the only academic medical center in Central Ohio and ranked as one of Americas Best Hospitals by U.S. News and World Report for 20 consecutive years! We are committed to comprehensive patient care, high caliber research and innovative medical education for medical students, post-doctoral trainees and professional colleagues.


The OSUCCC James is the only cancer program in the United States that features a National Cancer Institute (NCI)designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nations largest public universities.


Research Focus:

There is a postdoctoral scholar position available at the Ohio State University Comprehensive Cancer Center in the laboratory of Terence Williams, MD, PhD, for a highly motivated, creative, independent fast learner, with strong work ethic and critical-thinking abilities, seeking to perform high-impact research and publish in high-impact journals. Dr. Williams laboratory focuses on tumor metabolism, nutrient scavenging, autophagy, DNA repair, and DNA damage response signaling in multiple cancer types, including brain tumors, lung cancer, pancreatic cancer, thyroid cancer, melanoma, colorectal cancer, etc. As examples of his work, Dr. Williams lab was the first to identify a role for caveolae/Cav-1 in albumin uptake and nutrient scavenging, as well as important roles for BRAF and KRAS mutations in DNA repair and response to genotoxic therapies, including radiation. His lab actively studies caveolae-mediated endocytosis as a target for cancer therapy, how oncogenes (e.g. KRAS, BRAF) mediate resistance to therapy, how to harness cell cycle and cell cycle checkpoint repair pathways for therapeutic intent (e.g. Wee1, ATR, Chk1), developing novel RNA-based nanotherapeutics, and novel RNA-based signatures to predict outcomes and therapeutic response. Dr. Williams lab research studies span across cell line modeling, animal modeling (e.g. including transgenic mouse models), to research with human tissues from patients with cancer. Research findings have been published in Clinical Cancer Research, Cancer Research, Molec Cancer Therapeutics, Oncotarget, J Clin Invest, J Clin Oncology, J Thoracic Oncol, PNAS, Cancer, JAMA Surgery, IJROBP, R&O, J Biol Chem, Molec Biol Cell, Cell Cycle, and numerous other journals.


The long-term goals of the research are to better understand the underlying molecular mechanisms of how cancer cells perform nutrient scavenging as well as how oncogenes regulate DNA repair and DNA damage response signaling after therapy, which will hopefully lead to the identification of key molecular targets that engender improvements of therapy in solid tumors. His lab is dedicated to translational research, assessing molecular alterations in cancer models and patient tissues, and obtaining novel insights from the bedside. The laboratory collaborates with outstanding faculty in the Cancer Biology, Translational Therapeutics, and RNA Nanomedicine programs. There is a highly interactive work environment. All researchers will obtain great benefits within the large interactive environment of the OSU-CCC and College of Medicine, and will have great opportunities to interact with many talented investigators and researchers.


Dr. Williams research is currently supported by multiple NIH R01s, American Cancer Society, Radiation Oncology Institute, Florida Biomedical Research Program, NCCN, as well as OSU-CCC Pelotonia and internal funds. For additional details on Dr. Williams research please visit: https://u.osu.edu/williamslab/


Summary of Duties:

Perform basic or applied research in oncogenic signaling, tumor metabolism/nutrient scavenging, and DNA repair pathways to develop a better understanding of tumorigenesis and response to therapy, novel biomarkers and therapies for cancer treatment. Learn and use new techniques. Design research, perform experiments, collect and analyze data, writing manuscript.


Salary starting range is from $48,000-52,000/year for entry-level post-doctoral scholar.


Education/Experience (PhD degree required):

Doctoral Degree (Ph.D.) required; proficiency in molecular and cellular biology, biochemistry, cancer biology and mouse work is required.

To be considered for this position please send an updated CV, a brief description of research interests and contact information of three professional references to: terence.williams@osumc.edu.


Qualified candidates should apply online at: http://wexnermedical.osu.edu/careers. Enter keyword or job ID# 458555.


The Ohio State University offers a competitive salary, outstanding benefits, participation in workshops and conferences, high quality Shared Resources, and many opportunities for continued professional development.

The Ohio State University offers a competitive salary, outstanding benefits, participation in workshops and conferences, high quality Shared Resources, and many opportunities for continued professional development.

The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.


Apply with CV and Cover Letter

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Position

Post Doctoral Scholar