A PhD position is available in the laboratory of Professor Itay Rousso at the Ben-Gurion University. For successful infection, the HIV-1 genome, which is in the form of a single-stranded RNA enclosed inside a capsid shell, must be reverse transcribed into double-stranded DNA and released from the capsid (in a process known as uncoating) before it can be integrated into the target cell genome. The mechanism that triggers uncoating is a pivotal question of long standing. The projects available combine cell and molecular biology techniques as well as atomic force microscopy methods, to uncover the fundamental complex mechanism underlying uncoating. Knowledge in cell biology, virology, atomic force microscopy, or biophysics is encouraged.
The lab has a total of three AFM systems that are specifically designed for studying biological samples. These AFM systems are available for exclusive use of the lab. In addition, the lab has a tissue culture facility which is needed for producing and purifying viral cores required for these projects. This position is designed for highly motivated and dedicated individuals that are interested in joining a multi-disciplinary research at the cutting edge of biophysics.
Applicants should submit: 1) cover letter; 2) Curriculum Vitae; 3) A short statement of research interests; and 4) Names and contact information of referees to:
Prof. Itay Rousso
Dept. of Physiology and Cell Biology