Institute of Laboratory Medicine, Clinical Chemistry and
20 hours / week, limited contract (until 31.03.2021, with possibility of extension)
Salary scale of the University hospital Leipzig (UKL)
The earliest possible joining date is 01.04.2020
A PhD student position is available in the research group of Prof. Berend Isermann at the Institute of Laboratory Medicine at Leipzig University. The project aims at studying the role of coagulation proteases and Il1beta signaling across the blood brain barrier. The project will focus on the interaction between different cell types and the pathways governing these interactions. The main focus is to study cell-cell-interaction at defined barriers using in-vitro and in-vivo mouse models. Please also have a look at our publications: Ranjan, Isermann, Nature Commun 2017; Nazir, Isermann, Blood 2017; Kohli, Isermann, Blood 2016; Madhusudhan, Isermann, Nature Commun 2015; Shahzad, Isermann; Kidney Int 2015.
The project involves:
• Applying various cell culture methods to co-culture different cell types and to analyze maladaptative cellular communication (neurons, microglia, brain endothelial cells, astrocytes, pericytes)
• Investigation of different genetically modifies mouse models.
• Investigation of specific and novel molecular interactions in various disease conditions.
• Applying various methods of ex vivo analysis, including co-immunoprecipitation, western blotting and single-cell sequencing.
• Microscopic analysis techniques such as live cell imaging, immunohistochemistry, immunofluorescence and electron microscopy
• Successful completion of master’s degree in life sciences (biology, biochemistry, biotechnology)
• Relevant research experience (preferably international) and good English communication skills
• Comprehensive detailed knowledge in molecular biology, cell culture, mRNA, protein and DNA analysis epigenetics and cloning techniques
• Comprehensive detailed knowledge in cell culture, cell migration, cell proliferation, co-culture models and cell death are required
• In depth knowledge and experience in live-cell-imaging and microscopy techniques is desirable
• Applicants with experience in neurosciences are preferred
As a public employer in the heart of Leipzig, we stand for a corporate culture in which cooperation for the best care of our patients is paramount. As a maximum provider with 27 clinics and about 4,000 employees, we provide groundbreaking technical specialization as well as state-of-the-art structural and technical infrastructure.
Please send your applications not later than 20.04.2020 to email@example.com.
Your application should include:
1) Full curriculum vitae, publication list, information on years of experience in research and laboratory work including the methods you already know and you are experienced;
2) Names and contact information (email and telephone numbers) of 3 references;
3) A summary of research interests and long term plans;
Only shortlisted applicants will be notified.
By submitting your application, you agree that your personal data provided in the context of the application Data will be processed for the purpose of the application. The information on the collection and processing of personal data for applicants you will find here.
For information on the application process, please contact Dr. Ronald Biemann at 0049 341 / 97-22473 or firstname.lastname@example.org
The applications are accepted exclusively via the applicant portal.
Severely handicapped applicants are given preferential treatment if they are equally qualified. Please add appropriate evidence to your application.