Technical University of Munich (TUM)

PhD student (f/m/x) position in Computational Biology / Bioinformatics

Klinikum rechts der Isar university hospital of the Technical University of Munich

Munich, Germany

The Klinikum rechts der Isar university hospital of the Technical University of Munich is a major Euro pean center of medical care and education and teaching with 1,161 beds and around 5,500 employees. Every year around 60,000 patients benefit from inpatient and around 250,000 patients from outpatient care. The hospital is a supra-maximal care home that covers the entire spectrum of modern medicine. Since 2003, the Klinikum rechts der Isar is an institute of public law of the Free State of Bavaria.

The Department of Internal Medicine II at the Technische Uni versität München (TUM) and the Institute of Translational Cancer Research and Experimental Cancer Therapy at TUM and the German Cancer Research Center offer a

PhD student (f/m/x) position in Computational Biology / Bioinformatics

for translational cancer research with a focus on the analysis of single cell sequencing data

at the Center for Translational Cancer Research (TranslaTUM) in Munich.

We are deploying genetic models to study molecular, immunological and translational aspects of pan creatic cancer. We utilize these systems to uncover molecular mechanisms as well as inflammatory and immune pathways that are required for tumor initiation and progression in vivo (e.g.
Nature 2018, 554:62-68; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7; Cancer Cell. 2013,24:15-29, Cancer Cell. 2013,23:406-20, Nat Commun. 2013;4:1630; PNAS 2011, 108:9945-50). During the past decade, our lab has generated a comprehensive resource of pan creatic primary tumors and primary cell cultures. Multiple NGS methods have been performed to decipher the molecular makeup of these tumors. The advertised project focuses on unraveling tumor heterogeneity and its impact on treatment response and resistance using single cell sequencing techniques and will be performed in close collaboration with the Floßdorf lab (Dr. rer. nat. Michael Floßdorf) at TUM.

We are an enthusiastic and international team and offer intensive training and mentoring. The successful candidate will have the oppor tunity to:

  • Set up bioinformatics plat forms and develop computational pipelines for the analysis of single cell RNA-sequencing and single cell DNA-sequencing datasets
  • Integrate these data sets with molecular (WES, WGBS, lcWGS, ChIP-Seq, ATAC-Seq), phenotypic (e.g. histology) and clinical information
  • Apply bioinformatics techniques to published / unpublished data for the analysis and interpretation of omics datasets
  • Aid researchers select and use computational and statistical tools relevant to their single cell sequencing projects

The successful candidate will interact within a multidisciplinary environment of biologists, clinicians, computational scientists and mathematicians within the TranslaTUM. She / he will work closely with a diverse team to formulate hypotheses and validate predictions using genomic and transcriptomic assays. She / he will be exposed to cutting edge experimental methods to study trans lational aspects of cancer.

We are looking for an exceptional self-motivated computational scientist with a strong analy tical back ground. Previous exposure to and expe rience with bio informatics as well as interests in molecular aspects of cancer research are an asset, but not required. Due to the interdisciplinary framework and close collaboration with wet lab scientists, communicative skills are essential.

We give priority to severely disabled applicants with essentially equal qualifications. Payment according to tariff (TV-L).

We are looking forward to your application!

Interested candidates should send a CV with cover letter, certificates and letters of recommendation by e-mail to: dieter.saur@tum.de

Univ.-Prof. Dr. med. Dieter Saur
Institut für Experimentelle Tumortherapie
Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München

E-Mail: dieter.saur@tum.de

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PhD student (f/m/x) position in Computational Biology / Bioinformatics