PhD Position - SLC26 anion exchangers in intracellular chloride homeostasis

Jülich Research Centre (FZJ)

Jülich, Germany

Work group:

ICS-4 – Zelluläre Biophysik



Area of research:

PHD Thesis



Job description:

The laboratory of Christoph Fahlke in the Institute of Complex Systems – Cellular Biophysics is looking for a PhD student with a thesis project that focuses on the chloride homeostasis in the cytoplasm and in cell organelles. We are an interdisciplinary group focusing on the molecular and cellular function of membrane transport proteins (PNAS (2013) 110, 12486-12491, Cell (2015) 160, 542-553, Glia (2017) 65, 388-400, Nat Commun (2017) 8, 2279, EMBO J (2019) e101468) and on their dysfunction in genetic and acquired human diseases (Am J Hum Genet (2009) 85, 273-280; Brain (2012) 135, 3416-3425, Sci Rep (2017) 7, 13913, Nat Genet (2018), 50, 349-354).


Your Job:


The PhD project focuses on an anion exchanger that has been proposed to be critically involved in ischemic brain edema. We are interested in understanding the role of this transporter in setting anion concentrations in the cytoplasm as well as in intracellular organelles. Available methods range from molecular biology, fluorescence microscopy, fluorescence lifetime imaging, optogenetics to neuronal cell culture.


Your Profile:



  • Master degree in the field of Biology/Physics/Chemistry or related

  • High motivation and interest and/or experience in biophysics and biochemistry

  • Social competence and good communication skills for collaborative work in and with interdisciplinary teams

  • Ability to communicate in English

Our Offer:

  • Access to multiple techniques ranging from computational biology on individual proteins to the analysis of organ functions in animal models
  • Opportunity to get expertise in state-of art techniques and strategies in the field of molecular biology, fluorescence microscopy, fluorescence lifetime imaging, optogenetics, neuronal cell culture
  • Possible membership in the International Helmholtz Research School of Biophysics and Soft Matter www.ihrs-biosoft.de that provides a complementary research training at the interfaces of biology, chemistry, and physics, as well as transferable skills courses
  • A contract for the duration of 3 years
  • We will provide continuous scientific mentoring and discussions by the your scientific advisor
  • The doctoral degree will be conferred by the Heinrich Heine University, Düsseldorf
  • Outstanding scientific and technical infrastructure – ideal conditions for successfully completing a doctoral degree
  • Pay in line with 50 % of pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund).
  • Information on employment as a PhD student at Forschungszentrum Jülich can be found here www.fz-juelich.de/gp/Careers_Docs

Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations.We also welcome applications from disabled persons.


Please apply via recruiter’s website.

Quote Reference: 2020D-016