A 4-year PhD position is available at the Translational Neurology Group, Department of Clinical Sciences, Wallenberg Neurocentrum & Wallenberg Centrum for Molecular Medicine (WCMM), Lund University, Lund, Sweden.
Topic: “Pericyte signalling in CNS disease”
Background: In a time when the population is aging, the prevalence of neurodegenerative disorders is increasing. Yet, there is no treatment available to halt or reverse the ongoing neurodegenerative process.
Blood-brain barrier (BBB) disruption is a widely recognized common denominator of many neurodegenerative disorders.Integrity of the BBB is absolutely vital for normal neuronal function. Pericytes are cells that line the entire brain microvasculature. They represent a cell type that has key role in maintaining this homeostasis of the brain microenvironment and play a crucial role in brain pathology.
The purpose of this project is to characterize the role of pericytes in neurodegenerative processes. The candidate will systematically decode the specific molecular regulation of pericytes, identify key regulators and druggable targets in order to develop future novel treatments modulating pericyte function in disease.
Techniques: The project involves in vitro studies, in vivo animal models and analysis of human material. The candidate will learn techniques such as advanced microscopic techniques, microsurgery, cell isolation techniques, flow cytometry, single cell RNA sequencing, PCR and bioinformatics.
The group has a translational research focus on neuroprotection and neurorestoration. Translational Neurology is a member of centres of excellence (www.med.lu.se/multipark) and the Wallenberg Centrum for Molecular Medicine (www.wcmm.lu.se). The environment at Lund University provides excellent doctoral training with state-of –the art equipment, numerous guest lectures and workshops.
Candidates are eligible to apply if they have 240 high school points, a Master degree and preferably a very strong background in neurobiology and/or vascular biology. Candidates currently involved in Master programs are especially encouraged.
An outstanding academic performance and prior research experience is expected. We are looking for a highly motivated, hard-working, ambitious team player preferably with knowledge in immunohistochemistry, confocal microscopy, and experience in animal handling and/or cell culture.
Intended start: to be discussed
Please send a letter of motivation, your CV, contact details of 3 referees that have agreed to be contacted to Associate Professor Gesine Paul-Visse;
The application closes 1 april 2020