Max Delbrück Center for Molecular Medicine (MDC)

PhD position - Life Sciences

Max Delbrück Centrum for Molecular Medicine

Berlin, Germany

The MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE (MDC) is a member of the Helmholtz Association of National Research Centers, supported by the Federal Government of Germany and the Land Berlin. For our Molecular Oncology team, starting July or August 2019, we are lookingfor one

PhD position

Description:
The position is available in Dr. Michela Serresi’ s team at the MDC, Berlin, Germany. We seek to recruit an ambitious and self-motivated scientist with interest in molecular mechanisms of cancer metastasis.
The project deals with cancer metastasis derived from lung adenocarcinoma, which is the most common and severe complication arising in cancer patients and is currently incurable. A question in this field that is still very much open, is how a primary cancer cell acquires metastatic traits and what are the molecular events governing this process. Our research activity is to identify the main drivers of metastasis and clarifying their mechanisms of action. While next generation sequencing technologies allowed to better understand the genetic basis of cancer, discriminating alterations that are driving the processes of tumor evolution from passenger mutations still remains a major challenge. Moreover, extensive sequencing efforts of evolving primary and secondary tumors indicate that cancer genomes can be extremely complex and patients’ specific. Genetic screens represent powerful tools for identifying causal genes in various hallmarks of cancer progression. To address this topic, we are exploiting in vivo CRISPR-Cas9 screening strategies with dedicated and validated lung cancer animal models.
The project will combine advanced animal tumor models with genomic, epigenomic and computational technologies. Moreover, advanced microscopy techniques will be exploited for further characterization of distal organs colonization.
The MDC is a leading center for Biomedical Research in Europe (https://www.mdc-berlin.de/). As such, MDC offers an international research environment, interdisciplinary training, access to state-of-the-art technology platforms, and on-campus teaching lectures and workshops for career development.

Requirements:
For this position, the candidate is expected to have a genuine interest in Life Sciences, to be fully committed to the project and be enthusiastic about a collaborative environment.
As this position involves animal models, solid empathy towards patients and animals is an essential attribute.

Qualifications:
• A Master´s degree in Life Sciences
• Proven basic laboratory training
• Good spoken and written communication skills in English
• Proven experience in CRISPR/Cas9 or in vivo tumorigenesis will be a plus


The initial contract will be for a three years period. A 6-months probation period applies in compliance with the German law. Prolongation beyond 3 years is also possible upon mutual satisfaction. Conditions for extension are simple and will be clarified during the interview.

Salary is according to the German TVöD E 13 (Bund), 65 %. The MDC is an equal opportunity employer and supports gender equality.

The MDC is an equal opportunity employer and supports gender equality.

For further information please contact:
Michela Serresi
e-mail: michela.serresi@mdc-berlin.de

If your profile matches the description, please send your application including all documents (motivation letter, CV and contact details) indicating the registration number 11092/2019 until May 31, 2019 preferably by e-mail in a single pdf file as we do not return any papers to:

MAX DELBRÜCK CENTRUM FOR MOLECULAR MEDICINE
Personnel Department • POB 74 02 38 • 13092 Berlin
michela.serresi@mdc-berlin.dewww.mdc-berlin.de

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PhD position - Life Sciences