University of Southern Denmark (SDU)

PhD Position in Neuroproteomics and Brain Organoids

University of Southern Denmark (SDU)

Odense M, Denmark

Title: Revealing key signalling pathways underlying synaptic transmission in brain organoids.

Background:
Recently, the possibility to differentiate hiPSCs into organized 3D structures, brain organoids or mini-brains, has provided an efficient tool to study neuronal development using more mature neurons. Brain organoids are formed by cellular self-organization of neurons and astrocytes, resulting in the formation of distinct and interdependent brain regions ex vivo. Moreover, cerebral organoids developed over extended periods exhibit active neuronal networks, including the formation of organized and active synapses. The cellular diversity and 3D organization observed in brain organoids represent an advantage for modelling complex interactions observed in the neural microenvironment, including synaptic transmission in synaptosomes.

The project aims at developing and implementing brain organoids protocols and use the brain organoids to develop methods for characterization of synaptic transmission in neurons in the brain organoids using quantitative proteomics, PTMomics (modification specific proteomics), bioinformatics and imaging, followed by molecular and cellular biological follow-up studies.

Deadline: 3 September 2019.

Please see the full call, including how to apply, on www.sdu.dk.

Please apply via recruiter’s website.

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