The laboratory of Vascular Surgery (CHUV, Lausanne, http://cvalab.mystrikingly.com/) offers a 4-year PhD fellowship (funded by the Swiss National Science Foundation) to study ischemia reperfusion injuries during aging, under the supervision of Dr. Alban Longchamp.
Dr. Longchamp previous studies have uncovered key link between nutrient sensing, the pro-angiogenic gas hydrogen sulfide (H2S) and vascular aging (Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production, Longchamp A, et al. Cell 2018; Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging Das A, et al. Cell 2018.)
Our goal is to develop novel strategies, based on dietary intervention and hydrogen sulfide, to delay or revert aging phenotypes, especially in the context of ischemia/reperfusion injury and transplantation.
In addition, the student will have the opportunity to contribute to a prospective, randomized clinical trial to test the benefits of short-term dietary intervention before vascular surgery.
Candidates must hold a Master’s degree in Biology or Medicine and be acceptable for matriculation as a PhD or MD-PhD student at a Swiss University. Previous experience with mouse work is required. We are seeking a bright, enthusiast, and hard working scientist with academic ambitions. The successful candidate will have access to state-of-the-art technologies in metabolomics, cell biology, mouse model (including surgeries), and human sample, in an excellent, young, and dynamic environment. You will work in close collaboration with Vascular Surgeons, at the interface between medicine and research.