PhD position: Cryo-EM of autophagy assemblies

Jülich Research Centre (FZJ)

Jülich, Germany

Work group:

ER-C-3 – Strukturbiologie

Area of research:

PHD Thesis

Starting date:


Contract time limit:


Job description:

PI: Dr. Carsten Sachse

A PhD position is available for cryo-EM studies of autophagy assemblies at the ER-C-3 in the field of Structural Biology of the Forschungszentrum Jülich.

The research will be mainly carried out at the Forschungszentrum Jülich, which is one of the largest research centers in Germany, with excellent scientific equipment and leading European computational resources, located on a green campus, and near the cultural centers Köln, Düsseldorf, and Aachen.

The successful candidate should have a master degree in biochemistry/cell biology, biophysics or related field. The candidate will be working on high-resolution cryo-EM structure determination of purified autophagy complexes and/or in situ imaging of cellular samples using correlative light and electron microscopy approaches. The goal of the ER-C-3 institute is to shed light on the structural principles of the essential cellular maintenance mechanism of autophagy.

The Ernst Ruska Centre (ER-C) at the Forschungszentrum Jülich is one of the world-leading electron microscopy centres with a total of 13 electron microscopes including the PICO FEI Titan with a point resolution of 0.5 Å. The facility has been extended with state-of-the-art cryo-microscopes FEI Talos Arctica and FEI Talos 120. The Structural Biology division of the ER-C investigates the structural and molecular mechanism of autophagy and pushes the development of cryo-EM related methodology. The Jülich Supercomputing Centre operates a series of supercomputers including CPU and GPU architectures of highest performance. The Jülich campus hosts a vibrant biophysics and structural biology community.

The candidate will be working in a creative and international environment embedded in an interdisciplinary team with colleagues ranging from electron microscopists, computer scientists, biochemists as well as cellular biologists. The 3-year PhD position is immediately available. Payment of the PhD fellow will be based on salary grade EG 13 (50%) Collective Agreement for the Civil Service (TVöD).

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

Please apply via recruiter’s website.

Quote Reference: 2019D-005