PhD Position - Cancer Biology/Bioinformatics

Heidelberg University Hospital, Uni Heidelberg, Germany

Heidelberg, Baden-Wrttemberg, Germany

We are looking for a highly motivated PhD student with a strong interest in translational cancer research and/or high-throughput microscopy and 3D brain reconstruction. The aim of the project is to map the microenvironment of brain tumors by coupling mouse models with high-resolution serial-two photon tomography (STPT) imaging and/or light-sheet microscopy and iDISCO+. This is a collaborative project with Dr. Pavel Osten’s group at Cold Spring Harbor Laboratory, NY, USA. The Osten group has extensive expertise in high-throughput imaging, and image analysis pipelines.


Research group:

Our lab studies the roles of tumor suppressors and oncogenes in glioma initiation and progression. We use primary tumor models, single-cell genomics, and next-generation sequencing approaches to identify potential vulnerabilities that can be utilized for targeted therapies.

 

Project details:

The PhD student will join the Turcan laboratory at Heidelberg University Hospital, Heidelberg, Germany. The project is DFG-funded and initially limited to 3 years with the possibility of extension for 2 additional years. The work mainly includes in vivo mouse models of brain tumors. Using these models, we will perform single-cell/bulk (epi)genomics, and high-throughput light-sheet microscopy and/or STPT to map the brain tumor microenvironment. We plan to establish analytical pipelines for automated detection of cell types and morphologies, along with their 3D spatial distribution.

 

Eligibility requirements:

  • Master’s level degree in computer science and/or bioinformatics, or master’s level degree in biology with a strong focus on big data handling/image analysis.
  • Experience with computational biology and/or handling imaging data. Preferentially the candidate should be experienced in Matlab, R, and Python with machine learning applications.
  • Experience with molecular biology, cell culture methods, and mouse models are preferred, but not necessary.
  • Strong interest in interdisciplinary research.
  • Enthusiastic and highly motivated team player.
  • Excellent communication skills in spoken and written English.

 

Application:

If interested, please send your CV, degree certificate, transcript of grades, a summary of accomplishments/research interests, and contact information for three references to Dr. Sevin Turcan (sevin.turcan@med.uni-heidelberg.de).


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PhD Position - Cancer Biology/Bioinformatics