Umeå University (UmU)

PhD position: Autophagy

Department of Chemistry, Umeå University

Umeå, Sweden

Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. More than 4300 employees and 33 000 students from over 60 nationalities have already chosen Umeå University. The recent breakthrough researches from Umeå include deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 system and repurposing it into a tool for genome editing.

The Wu lab recently relocated from Max Planck Institute in Dortmund Germany to Umeå Sweden. The lab is located within the cross-disciplinary Chemical Biological Centre (video: ( at Umeå University. The lab is fully equipped for biological and chemical researches with access to excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. Facilities include Protein Expertise Platform, X-ray, Proteomics, NMR (850-400 MHz), Cryo-EM and Biochemical Imaging Centre (confocal, FLIM, spinning disk, TIRF, STORM).

Project description
Autophagy is an evolutionarily conserved self-eating process mainly to eliminate or recycle dysfunctional cellular organelles or unused proteins. Autophagy plays an important role in physiology including development and ageing and has been associated with diverse human diseases, including cancer, neurodegeneration and pathogen infection. Autophagy modulation is implicated in the treatment of diseases such as neurodegeneration and cancer. Despite extensive work, the mechanisms of autophagosome formation and autophagy regulation are not yet well established. Our laboratory has elucidated fundamental mechanisms underlying autophagosome formation and bacterial escape from host autophagy using chemical genetic approaches (eLife 2017, Angew Chem 2017, Nat Chem Biol 2019). We will combine cell biological, biochemical, and novel chemical and chemo-optogenetic approaches to understand the mechanism of autophagic membrane morphogenesis and bacterial interaction with host autophagy.

The project is interdisciplinary with strong international collaborations across scientific disciplines. The European Research Council (ERC) and Wallenberg Foundation are funding the research in long term.

Requirements and how to apply
For project details, requirements and how to apply: or use the button ‘Apply via Recruiter’. The last day to apply is 29 April 2020.

For further information you are welcome to contact Prof. Yaowen Wu

Please apply via recruiter’s website.

Quote Reference: AN 2.2.1-294-20