PhD in Phage Biology (f/m/d)

Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU)

München, Germany

Work group:

Institute of Virology



Area of research:

PHD Thesis



Starting date:

01.09.2019



Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.


At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you make an important contribution to the improvement of people’s quality of life.


The research focus in our lab is on the interaction of bacteria and viruses (phages). As pioneers in the development of “metaviromics” which involves isolating and sequencing the RNA/DNA from all of the viruses in sample directly, we query ‘wild’ viral populations to identify important key players or interesting strains, and evaluate various hypotheses using model-system approaches.


Ffor the newly funded ERC project to develop phage therapy, which utilizes phages or phage-derived inhibitors as natural ways to fight antibiotic resistance, we are seeking a highly motivated


PhD in Phage Biology (f/m/d)
2019/0329

Job description


The successful applicant will be involved in the development and the use of new methods and tools for illustrating bacteriophages infecting antibiotic resistant bacteria, including


targeted isolating, handling, analyzing phages on antibiotic resistant bacteria (both anaerobic and aerobic);metagenomic sequencing of phage community infecting certain bacterial hostsstudying the phage-host interaction using metatranscriptomic and metabolomic tools at both community and single-cell levelEngineer phages for therapeutic usages in a cell-free manner

Related publication:


Dzunkova M, Low SJ, Daly JN, Deng L, RinkeC, Hugenholtz P. Defining the human gut host-phage network through single-cell viral tagging. (2019) Nature Microbiology, accepted.


Elbehery AHA, Feichtmayer J, Singh D, Griebler C & Deng L. The Human Virome Protein Cluster Database (HVPC): A Human Viral Metagenomic Database for Diversity and Function Annotation. (2018). Frontiers in Microbiology 9, doi:10.3389/fmicb.2018.01110.


Deng L, Ignacio-Espinoza JS, Gregory A, Poulos PT, Weitz JS, Hugenholtz P, Sullivan MB. (2014) Viral tagging reveals discrete populations in Synechococcus viral genome sequence space, Nature 513, 242-245.


Your qualifications


Recent master in virology, microbiology, molecular biology or a related field Experience in any of the following areas: anaerobic bacteria cultivation and isolation, phage isolation and characterization, viral genomics, metagenomicsExperience with flow cytometers is advantageousFluency in English both oral and writtenHigh motivation, sense of responsibility, reliability and ability to work in a team

What we offer you


A challenging and versatile field of work providing you with the freedom to follow your instinct and be creative. With the help of extensive and goal-orientated professional development measures and career-building programmes we encourage you to grow as a person. To ensure a good work/life balance we assist you with flexible working hours, in-house health management, a nursery, child care subsidy where required and an “Elder Care” concept as well as other consultation and support options.


Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and research institutes it offers an intellectually stimulating environment.


The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.


Remuneration and benefits are in accordance with the collective agreement for the public service (EG 13 65% TV EntgO Bund).


The position is (initially) limited to three years.


Curious? If you have further questions, simply contact Judith Feichtmayer on (+49)-89-3187-94733, who will be happy to be of assistance.


Application


Please send your electronic application (in English) in a single PDF file – including CV and a complete list of publications, statement of research interests, and at least two reference letters – to the online application portal.



Please apply via recruiter’s website.

Quote Reference: 2019/0329

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