Hannover Medical School (MHH)

PhD candidate (f/d/m)

Hannover Medical School (MHH)

Hannover, Germany

The Institute of Molecular and Cell Physiology, Medical School Hannover is looking for talented and motivated PhD candidate (m/f/d) with an interest in cell biology, molecular biology, particularly in epigenetics and transcriptional regulation.

We welcome applications from candidates with a master degree in biomedicine, biochemistry, genetics, molecular biology, zoology and other related areas of life sciences.
The project work will start at the earliest possible date.

Project description:
Highly organized repetitive arrays of sarcomeres in striated muscle are responsible for generating force, thereby driving movements from molecular to organismic level. Optimal production and precise arrangement of sarcomeric contractile proteins are prerequisite for proper muscle function. The compromised ability to organize or to maintain the sarcomere structure leads to muscle disorders/myopathies. Muscle atrophy/Cachexia – an end stage muscle wasting disorder associated with cancer and several other diseases-severely perturbs muscle mass and function. Recently, we showed that cachexia targets distinct muscle contractile genes. By employing ChIPseq, RNAseq and proteomic tools, the proposed PhD project aims to investigate global changes in epigenetic profiles and transcriptional mechanisms targeted by cachexia signaling. For more information on the project background, check the following reference.

Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia. Nayak A, Lopez-Davila AJ, Kefalakes E, Holler T, Kraft T, Amrute-Nayak M. Cell Rep. 2019 May 28; 27(9):2725-2736.e4. doi: 10.1016/j.celrep.2019.04.107.

We offer:

  • PhD position (TV-L E13 50%).
  • An exciting project with defined objectives and clinical significance.
  • An international working atmosphere.
  • State-of-the-art research facilities with experts from interdisciplinary background.

What we are looking for:

  • We expect excellent academic scores, prior research experience.
  • Good knowledge in bioinformatics (Galaxy, IPA, R etc) and proteomics data analysis (MaxQuant, Cytoscape) is a strong plus.
  • Theoretical and basic practical knowledge in cell and molecular biology and biochemistry.
  • Analytical and goal-oriented approach towards project.
  • Preparedness to work independently, as well as in a team.

The application should include a CV, a short summary of previous research experience and a short description on why the candidate is interested in this project.
The position is funded with a Deutsche Forschungsgemeinschaft (DFG) grant for three years.

For more information on the lab’s research interests – visit the group site at – https://wr-test.mh-hannover.local/institute-zentren-forschungseinrichtungen/institut-fuer-molekular-und-zellphysiologie/mitarbeiter/innen/phd-arnab-nayak

The MHH is certified as family-friendly university and stands for the promotion of women in the professional life. Applications of women are particularly welcome. Severely disabled applicants with equal qualifications are given preferential consideration.
The Hannover Medical School (MHH), with about 10.000 employees the biggest company of Lower Saxony, is a university institution for research and teaching in the human and dental medicine and a university hospital of supra-maximum medical care. Research, teaching, medical care and administration work hand in hand in the integration model at the MHH-campus.

Application deadline: 31.03.2020

Reference number 326

You have any questions beforehand?
Mr. Dr. Arnab Nayak will gladly answer them for you:
Phone: +49 511 532 2094

Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

PhD candidate (f/d/m)