Pepgen Ltd

Peptide and conjugation chemist

Pepgen Ltd

Oxford, United Kingdom

Peptide and conjugation chemist

PepGen Ltd

Oxford

Job Title: Chemist – Peptide and conjugation chemist
Compensation: Salary dependent on experience (with bonus and share options)
Location: Bioescalator (https://www.bioescalator.ox.ac.uk)
Hours: Full-time (part time contracts will be considered)
Contract Type: Permanent

The company

PepGen is an Oxford-based biotechnology spinout with a view to transform genomic medicine through the development and translation of our innovative peptide-based drug delivery platform. Having spunout in 2018 following a successful, long term collaboration between the Universities of Oxford and Cambridge, we are currently in the process of advancing our technology towards the clinic. We are based in the Bioescalator in the new Innovation Building (amongst other entrepreneurial startups) in Oxford.

The Role


We are looking for a Peptide and conjugation chemist to join our growing team. They will be based in Oxford and work within the scientific team on the synthesis and purification of peptides and peptide-oligonucleotide conjugates. Aside from the skills outlined below, the successful candidate will have outstanding communication skills, the ability to take initiative, be highly organised and able to manage their time efficiently, and show a passion for science and its development to help achieve the mission of the company.

Responsibilities:

  • Peptide synthesis on a small to mid-scale by solid phase peptide synthesis (SPPS)
  • Peptide purification via prep reversed phase HPLC
  • Conjugation of peptides to therapeutic oligonucleotide moieties
  • Reporting results effectively in written reports and orally
  • Analysing results and suggesting next steps/optimisation
  • Maintenance of laboratory and laboratory equipment
  • Developing robust and reliable procedures suitable for others to follow
  • Keeping up to date with current state of the art in the field via journal articles, news press etc
  • Working according to stringent H&S policies

Essential qualifications and key skills

  • Educated to Masters level in Chemistry or related discipline. Exceptional Bachelors level candidates will be considered

Desirable skills

  • Previous experience in Industry in a lab-based role – highly desirable
  • Knowledge and previous experience of the stages of peptide synthesis and purification i.e. SPPS, RP-HPLC, MALDI-ToF. Candidates with Chemistry knowledge (but not with peptides) will be considered.
  • Previous experience of bioconjugation techniques and analysis e.g. gel electrophoresis
  • Knowledge of quality control procedures to ensure the standardisation of production batches
  • Interest in application of conjugates synthesised in subsequent biological testing

Applications (consisting of a CV and cover letter) or any queries can be sent to Smita Gunnoo: sgunnoo@pepgen.net

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Position

Peptide and conjugation chemist