Aarhus University (AU)

One or more postdoc positions in gene regulation in cancer

Aarhus University (AU)

Aarhus C, Denmark

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for one or two positions as Postdoc in the field of gene regulation in cancer as per 1 March 2020 or as soon as possible thereafter. The start date is flexible and the positions are fixed-term full-time positions for two years with a possibility for extension.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work in the brand new ‘Skou Building’ located at the Aarhus University Campus. You can read more about the department here and about the faculty here.

About the research group
The Laboratory for Gene-Regulatory Mechanisms in Cancer was recently established at the Department of Biomedicine at Aarhus University, with the aim to explore the interplay between genetics, epigenetics and non-coding RNAs in the development and progression of cancer. Recently, we have started to explore the functional role- and clinical potential of a newly described type of non-coding RNA, the circular RNAs, in brain tumours and haematological malignancies. Circular RNAs are extremely stable within our cells and carry out completely different functions relative to their linear cognates. To study these molecules, we use a combination of traditional molecular biology approaches and high-throughput technologies such as RNA-sequencing and NanoString technology (see: Kristensen et al. Nat Rev Genet. 2019 Nov;20(11):675-691.).

To ensure that the group is at the forefront of translational cancer research, we collaborate with leading pathologists, oncologists and haematologists as well as basic researchers in Denmark and abroad.

Assistant professor Lasse Sommer Kristensen, who recently received a 5-year grant for the project related to the open positions, leads the Laboratory for gene-regulatory mechanisms in cancer.

About the research project
Human cells produce more unique circular RNAs than we have genes, many of which are highly conserved and abundant. These molecules have strong gene-regulatory potential and their roles in cancer and other multifactorial diseases are just starting to be elucidated. This project aims to answer key questions related to the pathobiology of circular RNAs in haematological malignancies. In particular, we will use high throughput RNA-sequencing to perform a genome-wide profiling of all RNA species, including circRNAs, in cancer entities for which the landscape of circRNA expression is completely unknown. The project aim to elucidate novel genetic and epigenetic mechanisms behind aberrant circRNA expression in cancer, including how cancer-driving mutations in patients impinge on circRNA biogenesis. Moreover, to characterize the molecular functions of selected circRNAs being key drivers of cancer pathogenesis and potentially translate this new knowledge into clinical use through the use of large well-annotated clinical cohorts.

Your competences
You have academic qualifications at PhD level, preferably within one or more of the following areas: Non-coding RNAs including circular RNAs or RNA research in general, RNA-protein interactions, in situ visualization of RNA and protein, and cell biology and functional studies (e.g. using RNAi, CRISPR-Cas9 and overexpression vectors in cultured cells).

It will be beneficial if you possess bioinformatics/computational skills and strong scientific writing skills.

As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position
If you have any questions about the position, please contact Dr. Lasse Sommer Kristensen tel.: (+45) 2888 0562.

Your place of work will be the Department of Biomedicine, the Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.

We expect to conduct interviews January/February 2020.

Terms of employment


Application
Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • References/recommendations can be uploaded separately in the e-recruitment system
  • Template for applicant – postdoc must be completed and uploaded under ‘Extra documents’

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University’s website.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

Deadline:
08 December 2019

Please apply via recruiter’s website.

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