Applications are invited from suitably qualified candidates for a full-time fixed term position as a Postdoctoral Researcher in the Discipline of Surgery at the National University of Ireland Galway. This position is part of the Precision Oncology Ireland Network and is funded jointly by Science Foundation Ireland and the National Breast Cancer Research Institute.
The post is available from February 2020 with the potential for 2.5 years (30 months) employment.
Precision Oncology Ireland is a consortium of 5 Irish Universities, 6 Irish Charities, and 10 International companies aiming to develop new diagnostics and therapeutics for the personalised treatment of cancer. The consortium is part-funded by Science Foundation Ireland under their Strategic Partnership Programme. The shared vision is to combine cutting-edge genomics, proteomics, metabolomics and imaging technologies integrated through computational analysis and modelling to generate molecular profiles that allow us to better understand cancer pathogenesis, progression and response to therapies. Bringing together experimental and computational advances combined through data integration is a key competitive advantage of the POI consortium. The results will be better diagnostics, personalised cancer therapies, and acceleration of cancer drug discovery and development.
The Discipline of Surgery at NUI Galway accomodates a multidisciplinary team of scientists, clinicians and students with research collaborators locally and internationally. Research is based in the Lambe Insitute in the School of Medicine, and is integrated into the hospital campus. This project will focus on MicroRNAs (miRNAs) which play a key role in post-transcriptional regulation of gene expression within cells and are also actively secreted into the bloodstream. Expression of miRNAs is dysregulated in multiple cancer types, highlighting their potential as circulating biomarkers. We and others have shown that multiple miRNA expression profiles can classify breast cancer epithelial subtype, predict subtype specific survival, and impact response to systemic therapy. Initial studies have identified a panel of microRNAs predictive of response to neoadjuvant chemotherapy (NACT), potentially providing a way to more accurately select patients that will benefit from treatment. This project will involve establishing a prospective trial to validate the initial findings and support the identification of a panel of microRNAs that indicate the presence of disease, support subtype stratification and selection of the optimal personalised therapy.
Duties and Responsibilities (Summary):
- · Undertaking and developing research in the area of circulating microRNAs in breast cancer
- · Ensuring compliance with institutional ethics and General Data Protection Regulations (GDPR)
- · Supervision and training of postgraduate (PhD, MD) and undergraduate research students
- · Preparation of grant applications for external funding
- · Collaboration with other researchers, clinicians, students, technical and administrative staff
- · Participation in research conferences and meetings as required
- Regular reporting to funding agencies, Head of Discipline and senior staff
Essential Qualifications and Experience:
PhD qualification in biological sciences
Minimum of 2 years postdoctoral experience
Experience in Bio banking, working with clinical samples and associated ethics/GDPR, ideally evidenced through publication record
Translational science experience at the clinical and preclinical interface
Track record in molecular and cellular biology of cancer
Minimum of two publications in peer reviewed journals
Previous experience in supervision of Undergraduate and/or Postgraduate research students
Excellent interpersonal, communication and facilitation skills
Ability to meet deadlines and produce appropriate research reports
Ability to work effectively as a member of a team and on own initiative
Track record of successful funding applications appropriate to career stage
Experience of In Vivo models of Breast Cancer
Salary: €37,874 – €45,042 per annum (public sector pay policy rules pertaining to new entrants will apply)
Start date: Post is available from March 2020
For information on moving to Ireland please see www.euraxess.ie
Applications to be sent including 1) Cover letter outlining suitability for the post, 2) detailed Curriculum Vitae,and 3) contact details of three referees combined in one file should be sent via e-mail (in Word or PDF only) to email@example.com
Please put reference number Ref no: NUIG 030-20 in subject line of e-mail application.
Closing date for receipt of applications is Thursday, 20th February 2020
National University of Ireland, Galway is an equal opportunities employer