Astex Pharmaceuticals Limited

NMR Spectroscopist (ref: NMR/1219)

Astex Pharmaceuticals Limited

Cambridge, United Kingdom

Job Title: NMR Spectroscopist (ref: NMR/1219)

Job Type: 18 Month Fixed Term Contract (Maternity Cover)

Location: Cambridge, UK

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on oncology and neurological disorders.



We are looking for a self-motivated NMR spectroscopist to cover a period of maternity leave within Astex’s Molecular Sciences Group. The successful candidate will primarily be responsible for providing NMR support for Pyramid™, Astex’s proprietary fragment-based drug discovery (FBDD) platform and will be engaged in FBDD versus a spectrum of oncology and CNS targets. Your primary focus will be to enable and prosecute NMR fragment screening campaigns and to develop NMR-based affinity determination assays. You will be expected to work within, and communicate results to, inter-disciplinary project teams.

Key skills:

  • Practical experience in setting up, running and analysing NMR experiments on Bruker spectrometers on biological macromolecules, particularly proteins
  • Sound understanding of NMR theory
  • Organisation and communication skills and proactive working style
  • Expression and purification of (isotope labelled) proteins

Optional skills:

  • Experience with NMR automation & basic NMR spectrometer maintenance tasks
  • Experience with ligand-observed NMR experiments for probing protein small molecule interactions
  • Experience with NMR reporter assays
  • Expression of deuterated proteins and/or knowledge of insect cell expression systems
  • Good understanding of the physical principles underlying protein ligand interactions
  • Computational skills (Linux, scripting languages, …)
  • Other biophysical (ITC, Tm, SPR, MS) or structural methods (X-ray, cryo-EM)

To apply please send your CV and a cover letter, quoting the job reference: NMR/1219 to

Closing Date: 31th January 2020

For information on Astex Pharmaceuticals please visit:

and for information on Otsuka Pharmaceuticals please visit:


Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

NMR Spectroscopist (ref: NMR/1219)