Multiple positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute (disneylaboratory.org). In particular, we seek postdoctoral students to study the toxicity associated with inherited amyotrophic lateral sclerosis (ALS) and develop targeted RNA degradation tools and related technologies. We are committed to each individual’s development to achieve their short term and long-term career goals.
An overview of the laboratory’s efforts in small molecule targeting of RNA for chemical probe and lead medicine development is Journal of the American Chemical Society (2019) 141(17):6776-6790. Additional information can be found at the group’s website: www.disneylaboratory.org.
Representative publications in these area from our group include:
• Studying the RNA repeats that cause genetically defined ALS and dementia: Neuron (2014) 83(5):1043-50; Cell Chemical Biology (2018) pii: S2451-9456(18)30378-7; doi: 10.1016/j.chembiol.2018.10.018.
• Developing targeted RNA degradation tools and related technologies: Journal of the American Chemical Society (2018) 140(22):6741-6744; ACS Chemical Biology (2018) 13(11):3065-3071; Cell Chemical Biology (2018) 25(9):1086-1094.e7; Nature Chemical Biology (2017) 13(2):188-193.
• Developing precision targeted therapeutics for a variety of cancers and other diseases: Journal of the American Chemical Society (2019) 141(7):2960-2974
• Developing and implementing tools to facilitate the development of chemical probes and lead medicines targeting RNA:
Successful candidates will have a proven track record of publishing in high impact journals, experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as part of an interdisciplinary team. Expertise in RNA-seq data analysis is also highly desirable.
Applicants should send their CV and have three letters of reference sent to Prof. Matthew Disney at email@example.com.