University of Cambridge

MRC Postdoctoral Fellow

University of Cambridge

Cambridg, United Kingdom

MRC Postdoctoral Fellow
MRC Toxicology Unit, Cambridge
Reference: PU20844

The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy and offers excellent opportunities for postdoctoral development. The Unit is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in 2020. This post will initially be based at the MRC Laboratory of Molecular Biology (LMB), Cambridge, prior to relocation to the Gleeson Building.

We are looking to appoint an MRC Postdoctoral Fellow (PF) to join Mathew Van de Pette’s newly established lab “Epigenetic Mechanisms of Toxicity.” We will employ multi-disciplinary approaches, including in vivo longitudinal imaging, genomics, metabolomics and development of novel in vitro and single cell approaches.

You will work on a project exploring links between developmental exposure to pharmacological agents, either in isolation or in combination, and their impact on the developing offspring. You will explore potential phenotypes that are caused by the exposures, and monitor the extent of these changes. This project will use both wild type animals and a series of reporter mouse lines, that enable in vivo monitoring of an epigenetic state. There will be close overlap with other projects in the lab, which will require collaborative work between members. You will also have freedom to develop your own projects, in line with lab interests.

Applicants must hold, or be close to completing, a PhD in a relevant discipline such as Epigenetics, Physiology or Toxicology together with experience in mammalian genetics and molecular biology techniques. Experience in mouse studies is essential; in vivo longitudinal imaging and metabolic phenotyping would be advantageous but not essential. Experience of pregnancy studies is desirable. Submission of at least one first author international peer-reviewed paper is expected as is the ability to work both independently and as part of a team, together with excellent communication and critical thinking skills.

This is a three-year training and development position during which you will receive a range of formal and on-the-job training to ensure you receive the skills relevant to your role and to help support your future career.

Further information on the Toxicology Unit can be found at (

To apply online for this vacancy and to view further information about the role, please visit :

Closing date: 03 November 2019

Informal enquiries are invited and can be directed to Mathew Van de Pette at

If you have any queries regarding the application process please contact Rebecca Heatherley at

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Please quote reference PU20844 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please apply via recruiter’s website.

Quote Reference: Reference: PU20844