University of Cambridge

MRC Postdoctoral Fellow

University of Cambridge

Cambridge, United Kingdom

MRC Postdoctoral Fellow
MRC Toxicology Unit, Cambridge
Reference: PU20843

The Medical Research Council Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy and offers excellent opportunities for postdoctoral development. The Unit is currently located at Leicester and will physically relocate to the Gleeson Building, Cambridge in 2020. This post will initially be based at the MRC Laboratory of Molecular Biology (LMB), Cambridge, prior to relocation to the Gleeson Building.

We are looking to appoint an MRC Postdoctoral Fellow (PF) to join Mathew Van de Pette’s newly established lab “Epigenetic Mechanisms of Toxicity.” We will employ multi-disciplinary approaches, including in vivo longitudinal imaging, genomics, metabolomics and development of novel in vitro and single cell approaches.

This is predominantly a bioinformatics role where you will be working on a project exploring links between developmental exposure to environmental and pharmacological agents, and their impact on the embryonic and post-natal epigenome. There will be a focus on differentiating between transient and life-long changes in gene expression and multi-generational heritability of these changes. This project offers an exciting opportunity to determine how different exposures impact on specific regions of the epigenome, and whether these changes are permanent or transient. The ultimate aim of this project is to identify mechanistic similarities and differences in diverse exposures. Although mainly a bioinformatics role, the successful candidate will be expected to undertake a portion of the “wet lab” experiments, including in vivo work, alongside other lab members, however previous experience of this work is not required. You will also have freedom to develop your own projects, in line with lab interests.

Applicants must hold, or be close to completing, a PhD in a relevant discipline such as Epigenetics or Toxicology together with experience in bioinformatic techniques. This project will require significant time handling data sets; previous experience of handling RNA-Seq data sets and analysis of epigenetics marks is essential. Single cell genomics experience would be advantageous but not essential. Wet lab experience is also desirable, but relevant training would be provided. Working as part of a team within the laboratory environment is therefore desirable. Submission of at least one first author international peer-reviewed paper is expected as is the ability to work both independently and as part of a team, together with excellent communication and critical thinking skills.

This is a three-year training and development position during which you will receive a range of formal and on-the-job training to ensure you receive the skills relevant to your role and to help support your future career.

Further information on the Toxicology Unit can be found at (

To apply online for this vacancy and to view further information about the role, please visit:

Closing date: 03 November 2019

Informal enquiries are invited and can be directed to Mathew Van de Pette at
Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check and a security check.

Please quote reference PU20843 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Please apply via recruiter’s website.

Quote Reference: Reference: PU20843