University of Luxembourg

Marie Skłodowska-Curie ITN Early Stage Researcher in MIRIADE: Multi‐omics Interdisciplinary Research Integration to Address DEmentia diagnosis

University of Luxembourg

Luxembourg, Luxembourg

The University of Luxembourg is a multilingual, international research university.

The Bioinformatics Core at the Luxembourg Centre of Systems Biomedicine (LCSB) has the following vacancy:

Marie Skłodowska-Curie ITN Early Stage Researcher in MIRIADE: Multi‐omics Interdisciplinary Research Integration to Address DEmentia diagnosis

LCSB is a leader in the area of development and application of computerized, mechanistic disease models. As a part of the Marie Skłodowska-Curie ITN MIRIADE we work jointly with a multidisciplinary team of scientists from academia, industry, and patient organisations across Europe on systems biomedicine approaches to optimise and accelerate development of novel biomarkers for dementia. We are looking for a young scientist that will help us with this effort.

Your main tasks and responsibilities

- To integrate available (public and own) datasets of dementia and to make them available to the consortium and the broad research audience via a dedicated data platform;
- To screen these integrated datasets for candidate biomarker molecules;
- To develop a Dementia Disease Map based on the key dementia mechanisms, candidate molecules and existing knowledge repositories;
- To propose new protein-antibody interaction algorithms based on the collected data and disease map;
- To communicate results by means of oral presentations and scientific publications.

As early stage researcher you work in close collaboration with the head of the research group (Prof. Reinhard Schneider), a senior researcher (Dr. Venkata Satagopam), and a second supervisor (Dr. Kirsten Roomp). You will be part of a young, multidisciplinary team, with ample experience, and an excellent position within the field of data integration and disease modeling.

What do we expect

We are looking for a highly motivated and enthusiastic early stage researcher with a strong interest in dementia, bioinformatics and data science. You are pro-active and precise, have excellent communication skills, a talent for organising, and work optimally when collaborating with others. You like to solve scientific problems. You have an intrinsic motivation and capacity to continuously improve yourself.

To be eligible for this position, the applicants must satisfy the following requirements, conform to the Marie Curie admission requirements:
- Must not already hold a PhD
- Must be within the first four years (full-time equivalent) of their research career
- Must not have resided or carried out their main activity (work, studies, etc.) within Luxembourg for more than 12 months in the three years immediately prior to their recruitment.

In addition, you meet the following requirements and experience:
- Aiming to obtain a PhD degree;
- Excellent communication skills in English, both written and verbal;
- Research master’s degree in the field of computer science, bioinformatics or related. Training in biomedical data integration or systems biomedicine is considered an advantage;
- Experience in writing (international) publication(s);
- Ability to generate scientific outputs for publication in peer reviewed journals;
- Willingness to travel to attend secondments, training and academic events;
- Ability to work within an internationally diverse team and to comply with the requirements of the funder.

Your working environment

Bioinformatics Core at the LCSB is an enthusiastic team working in the area of translational medicine. We offer our expertise and infrastructure for biomedical data integration and visualization to our centre, but also national and international partners. The research group has strong expertise in developing standardized, reproducible data operations for clinical and life sciences collaborators. We also work on multi-scale disease models and approaches to combine them with available data for better understanding of disease mechanisms.

The MIRIADE project

The project MIRIADE is being pursued in the framework of the Marie Skłodowska-Curie Innovative Training Network. The overarching goal of the MIRIADE project is to train a novel generation of scientists able to accelerate dementia biomarker development. MIRIADE comprises of ten world-leading research organisations, 5 small to large industries and 2 patients organisations, from 12 countries in the EU, South-Korea and USA. A total of 15 Early Stage Researchers (ESRs) will be hosted across the network. The project will leverage existing proteomics datasets to identify the most promising candidate biomarkers for the major forms of dementias. It will develop an openly accessible integrated data platform for biomarker development (ESR1). ESR project 2 will focus on the prediction of protein-antibody interactions success in biomarker assay development. ESR3 will characterise protein surface accessiblility states in specific biological matrices, to improve biomarker assay development. ESR4-6 will develop specific reaction monitoring assays and validate these in CSF and blood of patients with AD (ESR4), FTD (ESR5) or DLB. ESR7-10 will develop novel immunoassays in CSF and blood for all dementias (ESR7); AD (ESR8), FTD (ESR9) or DLB (ESR10). ESR11 and 12 will focus on the market-ready development of plasma abeta42 and abeta40 assays (ESR11) or neurofilament light (ESR12). ESR13 will develop reference methods for SRM assays for amyloid and neurofilament light CSF and blood assays. ESR14 and 15 will focus on innovation of the process, in order to generate a roadmap for efficient biomarker development. ESR14 will study how data are organized, shared, reused and integrated in academia and ESR15 will compare and evaluate different workflows of biomarker development.

What we offer

Successful candidates will receive an attractive base-salary in accordance with the Marie Skłodowska-Curie Actions, for 36 months. The exact (net) salary depends on the EU-defined country correction factor, and on local tax regulations (for additional information see EU MSCA website).

Next to your local PhD training, you will participate in an attractive educational program customized to the MIRIADE early stage researchers. The MIRIADE training program consists of annual training weeks across Europe to optimally develop your academic and transferable skills, as well as the basis of innovation and entrepreneurship. This training program prepares you for a prosperous career as biomarker expert.

Fellows will also benefit from a mobility allowance. In addition a family (if applicable) allowance (an additional financial allowance paid with the salary) is on offer to fellows with a spouse &/or child/children at time of recruitment. Successful applicants are eligible for parental leave in keeping with Amsterdam UMC standard employment policy.

If you don’t have the nationality of an EU/EEA country or Switzerland, you need a residence permit in the Luxembourg. We will help you with the application for this.

Applications should contain the following documents:
• A detailed curriculum vitae
• A motivation letter
• Name and addresses of three referees

Applications should be addressed to Prof. Reinhard Schneider, Head of the Bioinformatics Core facility at the Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg

Review of applicants will begin immediately and will continue until the position is filled.
For further information, please contact Marek Ostaszewski (marek.ostaszewski@uni.lu)

Please apply before January 15th, 2020 with reference number.

The University of Luxembourg is an equal opportunity employer.

Please apply via recruiter’s website.

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