King's College London (KCL)

Marie Sklodowska Curie Early Stage Researcher

King's College London (KCL)

London, United Kingdom

Marie Sklodowska Curie Early Stage Researcher

Wolfson CARD

R5/1076/19-HH

014106

The salary will be paid EU grade – Basic £ 33,884

This post also qualifies for an additional Marie Curie Allowance in the range of £4,447-£8,153 per annum, exact allowance to be determined at appointment

This post will be offered on a fixed-term contract for 3 years/36 months.

This is a full-time post – 100% full time equivalent

The selection process will include a panel interview, an assessment, and a presentation.

We invite candidates to interview for the position of Early Stage Researcher investigating mechanisms of cancer pain. This position, based at the Institute of Psychiatry, Psychology and Neuroscience at King’s College London, is part of the BonePain II project (www.bonepain.eu).

Strict eligibility criteria apply and the successful candidate must not have resided or worked in the UK for more than 12 months in the last 3 years. Further, the successful candidate must not have been conducting research for more than 4 years.

Pain is a debillitating and often poorly controlled symptom of bone cancer. The growing problem of opioid abuse and lack of suitable therapy means that the search for alternative analgesics is of high importance. We have models of good face validity of bone cancer pain in rodents and we know that a primary cause of pain in both patients and in the animal models is sensitization of the neuronal circuitry reporting on the status of bone. The project will focus on in vivo studies in which neuronal activity is monitored indirectly via Ca imaging. Sensors such as GCaMPs are expressed in peripheral or central pain signalling neurones in rodents. In vivo optical recording of nociceptive activity is a new development that is not widely available. It allows parallel recording of multiple pain-signalling neurones. We will use it here to characterise the sensitization of nociceptive circuits in normal animals and in models of bone cancer pain while testing the effects of novel analgesic agents. Further, central plasticity in rodent early and late stage bone cancer will be anatomically and functionally defined.

BonePainII is a European Innovative Training Network to promote frontline research, innovation and education within bone pain. The BonePainII network has participants from 6 European countries and encompasses 8 academic groups and 4 industries all committed to creating an outstanding training program for 15 early stage researchers (ESRs), each with the common aim to elucidate the mechanisms of bone pain and develop new medicines.

As part of the MSCA ITN scheme, it is expected that the candidate will register for and work towards a PhD degree, with the aim of completing this within the fixed term of appointment. The candidate will also be expected to work closely with the other Early Stage Researchers, both at own and at other participating institutions; to go on secondment at one or more of the BonePainII institutions, and to participate to the Network-wide training program.

Stephen McMahon +442078486270/Stephen.mcmahon@kcl.ac.uk

Kirsty.bannister +442078484617/Kirsty.bannister@kcl.ac.uk

Closing date: 9 June 2019

To apply, please visit https://my.corehr.com/pls/kingrecruit/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=014106 and register with the King’s College London application portal and complete your application online.

Please apply via recruiter’s website.

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