Francis Crick Institute

Laboratory Research Scientist

Francis Crick Institute

London, United Kingdom

LRS Job Description 

 

Job title: Laboratory Research Scientist

 

Reporting to: Eachan Johnson, Group Leader

 

Contract term: This is a full-time, fixed term (2 years) position on Crick terms and conditions of employment. 

 

Salary for this Role: From £29,150, with benefits, subject to skills and experience.


The Role

The role of a Laboratory Research Scientist in the Crick is diverse and rewarding. The role covers a wide range of different functions and allows for continuity of lab operations. The role offers support to one or more scientific projects or programmes. Typical activities include:

 

• Collaborating with other lab members on research projects. 

• Providing experimental or technical support to other lab members. 

• Providing technical expertise for the development, refinement and troubleshooting of relevant methodologies. 

• Participating in academic activities, including group meetings and journal clubs, seminars, and scientific meetings. 

• Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring budgets, and routine maintenance of laboratory equipment.  

• Training and supervising other lab members in key techniques and protocols, lab operations, and equipment use. 

• Liaising with Science Operations and attending key quadrant meetings.

• Writing risk assessments and SOPs and providing safety guidance to lab members.

 

The Research Group

The Systems Chemical Biology of Infection and Resistance Lab studies how pathogenic bacteria survive and infect, using chemical biology and genetic tools to define new gene targets and their chemical inhibitors. Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to evolve resistance to antibiotics. Working at the interface of genetics, chemical biology, and machine learning, we discover and use small molecules to precisely disrupt the cellular machinery of pathogenic bacteria and study consequent effects on survival, infection, and evolution.

We primarily study Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), and Klebsiella pneumoniae, the cause of many antibiotic resistant hospital- and community-acquired infections. We use small molecules to complement genetic studies because they are easily applied to disparate cell types and species, precisely perturb specific functions of multifunctional gene products, and directly bridge the gap between implication of genes in disease and new therapeutics.

The Systems Chemical Biology of Infection and Resistance Lab opened in January 2021 and is supported by Crick core funding, the BBSRC, and the UKRI Horizon Europe Guarantee. We work with cutting edge Scientific Technology Platforms including Advanced Sequencing, Flow Cytometry, Proteomics, Metabolomics, and High-Throughput Screening. The lab currently has nine members with a balanced mix of postdocs and PhD students, with a Senior Laboratory Research Scientist. Over the next two years, we expect to expand to twelve people. 

 

Key responsibilities

These include but are not limited to:

  • Liaising with Scientific Technology Platforms
  • Optimising phenotypic assays in Mycobacterium tuberculosis
  • Assisting deployment of high-throughput compound screens to discover new antimicrobials
  • Analysis of high-throughput screening data

 

Experience and Competencies

The post holder should embody and demonstrate our core Crick values: 

Bold; Open; Collegial

 

Essential

  • BSc (or equivalent) in chemistry, chemical biology, molecular biology, microbiology, systems biology, biological engineering, or related field
  • Ability to work independently and as part of a team
  • Ability to work towards agreed-upon goals
  • Strong oral and written communication skills
  • Excellent organisational skills
  • Enthusiasm and initiative to develop new skills and new methods
  • Motivation to use interdisciplinary and quantitative approaches to answer scientific questions

Desirable

  • Understanding of next-generation sequencing platforms
  • Familiarity with cell-based high-throughput screening assays
  • Experience with Python or R
  • Ability to prioritise and manage own time
  • Ability to communicate and present data

 

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

  • If you are interested in applying for this role, please apply via our website.
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 
  • If you require a visa to work in the UK we will help support your application should you be successful

 

Equality, Diversity & Inclusion

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

 

For more information on our great pay and benefits you can read more here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

 

 

 

Please apply via recruiter’s website.