The University of Texas MD Anderson Cancer Center

Institute Group Leader – Drug Discovery Biology

MD Anderson Cancer Center

Houston, TX, United States

MD ANDERSON THERAPEUTICS DISCOVERY DIVISION Within The University of Texas MD Anderson Cancer Center lies a powerful engine driving the future of new targeted, immune- and cell-based therapies: the Therapeutics Discovery Division. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery, with a multidisciplinary team of dedicated researchers, doctors, drug developers and scientific experts working together to develop small-molecule drugs, biologics and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently – all under the same roof. The Therapeutics Discovery Division is built around four platforms: The Institute for Applied Cancer Science (IACS), ORBIT (Oncology Research for Biologics and Immunotherapy Translation), TRACTION (Translational Research to Advance Therapeutics and Innovation in Oncology) and the Neurodegeneration Consortium. The IACS platform is focused on discovering and developing the next generation of small-molecule targeted therapies, driven by the needs we see in our patients. The team aligns world-class drug discovery and development research with the science and clinical care for which MD Anderson is known. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively. This model already has achieved results, with multiple programs currently in clinical and late-stage preclinical development. We are currently seeking a highly motivated and talented Group Leader of Drug Discovery Biology. This individual will be a key team member in the organization co-leading cross functional teams to advance projects from target validation through preclinical development to clinical proof-of-concept studies, in collaboration with MD Anderson researchers. The ideal candidate should have deep knowledge of cancer biology, strong translational science skills, and a proven track record of successfully leading multi-disciplinary small molecule teams from target validation through early clinical development in a biotech or pharmaceutical environment. Building on our unique model of drug discovery, the group leader will work closely with academic and clinical collaborators to integrate innovative biology with clinical research data to position IACS small molecule assets for clinical success. As a member of our R&D leadership team, this individual will play an essential project leadership role and will be empowered to provide strategic input to guide portfolio management decisions. By joining the Therapeutics Discovery Division, you have the opportunity to use your talents to make a direct impact on the lives of our patients. Join us, and lead our next program from concept to clinic. KEY FUNCTIONS: 1. Lead target and translational biology efforts on multiple IACS drug discovery projects, leveraging resources from cross functional areas, to deliver compelling translational data sets to advance IACS drug discovery programs into clinical proof-of-concept trials in distinct patient populations. 2. Serve on the R&D Leadership team, providing strategic insight to influence IACS portfolio strategy. 3. Plan and execute the translational research strategy for one or more targets, inform on target mechanism of action, and explore translational hypotheses. 4. Apply knowledge of pharmacology and biomarker development to enable in vivo assessment of chemical matter and establish pharmacokinetic, pharmacodynamic, and efficacy relationships. 5. Coordinate, direct and lead a team of successful internal scientists, and collaborative relationships and alliances with internal and external partners to drive innovation and influence the IACS portfolio. 6. Contribute to project team through lab based activities. 7. Resource projects in a flexible manner, including efficient use of outsourcing. 8. Secure the intellectual property rights, including drafting of patent applications. 9. Complete the necessary documentation for IND- and other regulatory filing, and for any due diligence or licensing activities. 10. Represent the Therapeutics Discovery Division externally through presentations at key National/International meetings. 11. Proactively identify, evaluate and implement novel technologies to support translational activities. 12. Supervise, mentor, and professionally develop a team of dedicated research and associate scientists. Education Required: PhD in one of the natural sciences or related field or Medical degree. Preferred: PhD, MD or equivalent degree in Biology, Cell Biology, Pharmacology or related field. Experience Required: Seven years experience of relevant research experience in lab. Preferred: 7 years of relevant research and management experience beyond post-doctoral research maintaining hands-on experience. 1.Demonstrated ability to lead multidisciplinary project teams, with experience advancing small molecule assets through discovery into clinical development. 2.Experienced manager of people and projects including demonstrated ability to grow new leaders and delegate key projects appropriately. 3.Extensive knowledge in cancer biology including cell signaling, metabolism, epigenetics, and immune-oncology. 4.Deep understanding of preclinical PK/PD/efficacy relationships as they relate to small molecule drug discovery in oncology; translation of findings to the clinic. 5.Knowledge of preclinical and clinical biomarker discovery and development. 6.Demonstrated ability to function efficiently in a multi-disciplinary team environment 7.Evidence of independent thinking and leadership skills are vital. Ability to work well under pressure and drive projects that impact critical timelines is essential 8.Outstanding written and oral communication and negotiation skills are essential 9.Strong leader with focus and drive to succeed It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html SONJ Additional Information Requisition ID: 126688 Employment Status: Full-Time Employee Status: Regular FLSA: exempt and not eligible for overtime pay Work Week: Days Fund Type: Hard Pivotal Position: No Minimum Salary: US Dollar (USD) 148,500 Midpoint Salary: US Dollar (USD) 185,750 Maximum Salary : US Dollar (USD) 223,000

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Quote Reference: MD Anderson-md_anderson-4432_126688

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