Title of project:
Human inducible stem cells: novel approaches to study disease and personalized medicine.
A PhD position is open in Prof. Anna Lauber-Biason’s lab, at Division of Endocrinology of the Section of Medicine of the University of Fribourg, Switzerland, to study the molecular mechanisms of sex development in humans.
Our group is part of the Department of Endocrinology, Metabolism and Cardiovascular System that offers a multicultural and diverse environment.
Objective: The main objective of the work is the elucidation of the molecular basis of human sex development to better define phenotypes and therapies of its complex defects.
1. Gain new insights in sex differentiation in humans.
2. Create new models for understanding mechanism of disease.
Technically, the focus of the work will be to create human male and female gonadal cells from inducible pluripotent stem cells directly from patients affected by differences of sex development to study the mechanisms that lead to disease. We will also employ standard cell and molecular biology, genetics, biochemistry, exome and RNA-sequencing, CRISP-Cas9 gene editing and mass spectrometry techniques.
Bioinformatic analysis of next generation sequencing data and 3D-modeling is also one of our expertise.
Ideal profile: Applicants must hold a master degree (minimum 90 ECTS) or equivalent and have a strong background in biochemistry, molecular and cell biology. Previous experience in these fields as well as a broad interest in translational research will be important selection criteria as are the educational background, motivation, independence and creativity.
The successful candidate is expected to have good English communication and writing skills. Knowledge of German or French is of advantage.
Ideally, the candidate should be able to come to Fribourg for a personal talk.
Salary: according the Swiss National Science Foundation criteria
Duration: 4 years
Interested applicants should send a brief description of research interests, curriculum vitae and the names of three references to:
Anna Lauber-Biason, M.D.
Chair of Endocrinology
Faculty of Science and Medicine
University of Fribourg
Chemin du Musée 5
The University of Fribourg is Switzerland’s only bilingual university, offering a full academic curriculum both in French and German. A number of Master programmes are taught in English and the University offers a wide range of opportunities for PhD and doctoral studies as well as international Exchange and Summer School Programmes.
The University of Fribourg places scientific research that is closely linked to academic teaching at the heart of its activities. With an array of centres of scientific excellence as well as research programmes across the entire disciplinary spectrum, we aim to extend the frontiers of scientific knowledge to help solve mankind’s current and future challenges.