Washington University in St. Louis (WUSTL)

Host Microbial Interactions and Gastrointestinal COVID-19

Washington University in St. Louis (WUSTL)

St. Louis, MO, United States

Postdoctoral Scholar Opening

Host-Microbial Interactions and Mechanisms of Gastrointestinal COVID-19

The Ciorba Lab in the Division of Gastroenterology at Washington University in Saint Louis is seeking a motivated post-doctoral fellow to join our mission driven research team to lead studies on host-microbial interactions in intestinal health and disease. The successful candidate will join our team’s NIH supported efforts to define the mechanisms of intestinal COVID-19 and its interactions with IBD using novel mouse models of COVID-19, human biospecimens, molecular microbiology/virology, and human organoids.

These NIH funded studies will be in close collaboration with our expert virology/microbiology team including Siyuan Ding ( @sding88 ), Michael Diamond ( @msdiamondlab ), and Megan Baldridge ( @baldridge_lab ).

We are a diverse, team-oriented, basic-translational lab researching mechanisms and pathways of intestinal disease https://ciorbalab.wustl.edu. Ultimately, our goal is to leverage this understanding to identify novel therapeutic approaches that will address the unmet needs of patients affected by gastrointestinal diseases including COVID-19, inflammatory bowel disease (IBD: Crohn’s disease, ulcerative colitis), colon cancer. A major investigational focus is on the intestinal epithelium and intestinal stem cell function during cycles of injury and repair. Our lab is integrated with and benefits from the resources of the WashU Inflammatory Bowel Diseases Center of Excellence. https://ibd.wustl.edu   

We were among the first labs in the world to demonstrate that SARS-CoV-2 could infect human intestinal epithelial cells DOI: 10.1126/sciimmunol.abc3582 and were also the first lab to develop a specific model of intestinal COVID-19 https://doi.org/10.1093/ibd/izab274. Using this expertise and these tools we will address:

  • What mechanisms of disease drive GI symptoms in patients with COVID-19?
  • How does SARS-CoV-2 infect the gut, where does it go from there, and how is it cleared?
  • What role does the host microbiome/virome modulate GI COVID-19?
  • How does SARS-CoV-2 infection interact with pre-existing chronic intestinal inflammation?
  • How does SARS-CoV-2 infection in the GI tract contribute to long-haul COVID-19?

The postdoctoral scholar will have the opportunity to work with welcoming collaborators across the GI division, the School of Medicine and across the US to develop this project. They will also be encouraged to develop their own project as a launching board for an independent research career. This position is in the Division of Gastroenterology on the Medical School Campus. The GI division has an NIH-NIDDK funded Digestive Diseases Research Center (https://ddrcc.wustl.edu/) with numerous resources for investigation and funding. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Career Center, Teaching Center, Office of Postdoctoral Affairs, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs/.

How to apply: Please send a C.V., cover letter, and list of three references with contact information to Dr. Matthew Ciorba at ibd@wustl.edu. Use subject line “Post Doc”

Benefits Statement: Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Please visit our website at https://hr.wustl.edu/benefits/

Diversity Statement: We are dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals committed to these values are encouraged to apply.

Apply with CV and Cover Letter

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Position

Host Microbial Interactions and Gastrointestinal COVID-19