Two exciting opportunities are available to join the Functional Genomics department as part of the Gene Editing and Genetic Screening group. This group is working to unlock the genetic clues which underly human disease, thereby delivering new and better medicines. In the role you will utilise the power of CRISPR in high-throughput to enable the discovery and validation of novel disease targets or genetic variants, to elucidate genetic interactions, or understand mechanisms of drug action and resistance.
Working in a multi-faceted, dynamic, and cutting-edge scientific environment, this laboratory-based role will give you the opportunity: a) to apply your molecular and cell biology expertise to build and support functional genomic screens, b) obtain practical experience in target identification and validation, c) build expertise in the field of immunology or oncology; d) work with key partners across the business and interface collaboratively across local and global matrix teams.
Key Responsibilities include, but are not limited to:
- Designing and implementing focused or genome-wide CRISPR screens, employing physiological- and/or disease-relevant cellular models and assays.
- Employing molecular characterization of samples at genomic, RNA, and protein levels.
- Developing and running phenotypic assays such as FACS and cellular imaging.
- Working in a GLP Laboratory, and maintaining relevant standards for this environment
- Working in a matrix team environment to enable delivery of project and department objectives to the highest possible scientific standard.
- Ensuring compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices.
- Communicating experimental findings effectively, in written and verbal formats
Success in this position will require technical knowledge as outlined in the interview, combined with excellent analytical skills and problem-solving abilities. You will need to be a real team worker, with advanced interpersonal and communication skills, able to engage stakeholders both in the department and from other groups. You will be a highly committed, enthusiastic and motivated person with a passion for learning and an inquisitive nature, which enables you to seek answers to complicated scientific questions. As this is a constantly developing field, you will need to be a quick learner, adaptable and able to deliver impact quickly with new tasks and new technologies.
CLOSING DATE for applications: Sunday 5th January (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- MSc or equivalent experience in genomics, molecular or cellular biology.
- Broad experience and in-depth knowledge in CRISPR gene editing at single gene or screening level
- Experience in a broad range of molecular & cellular biology techniques
- Extensive experience of primary/recombinant cell culture
- Demonstrable experience solving scientific problems.
If you have the following characteristics, it would be a plus:
- Experience in single cell analysis methodologies.
- Demonstrated experience in working with complex in vitro models such as organoids/spheroids and/or tumour:immune models
- Proven experience in immunology or oncology research
- Familiarity with genetic, proteomic, imaging, and/or other ‘omics technologies
- Ability to formulate and communicate a coherent vision/research plan.
- Strong enterprise behaviour working within multidisciplinary teams.
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
- Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
- Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
- Continuously looking for opportunities to learn, build skills and share learning.
- Sustaining energy and well-being.
- Building strong relationships and collaboration, honest and open conversations.
- Budgeting and cost-consciousness.
*This is a job description to aide in the job posting, but does not include all job evaluation details.