Fully-funded PhD positions – Life Sciences
Department of Medical Biology, University of Quebec at Trois-Rivieres, Quebec, Canada
The Laboratory for Research on Stem Cell Regulation in the Department of Medical Biology at the University of Quebec at Trois-Rivieres (UQTR), directed by Dr Patrick Narbonne, is seeking highly-motivated PhD students to join his young and dynamic research team. His laboratory is dedicated to solving the in vivo cellular and molecular mechanisms that regulate stem cell proliferation. He mainly uses the nematode C. elegans, and more particularly, its germline stem cells, as a model system to solve this important biological problem. He recently found that stem cell proliferation rates are coupled to the needs for new differentiated cells in the tissue they sustain. He identified several genes implicated in this process, such as PTEN, LKB1, AMPK and ERK/MAPK (Narbonne et al. Development, 2015; Narbonne et al. PLOS Genetics, 2017) but much remains to be clarified, including the cells/tissues in which these genes are required. Various projects are available, ranging from identifying and cloning new genes implicated in stem cell regulation, through an established forward genetic screen, to elucidating the precise cell and molecular mechanisms by which these genes control stem cell proliferation, using state-of-the-art techniques, including CRISPR/Cas9-mediated genome editing, and equipment. Although there is a preference for the candidates to join at the PhD level, highly-motivated individuals at other stages in their careers, such as MSc or postdoc, may also be considered. Positions will remain opened until filled.
The Narbonne laboratory is located at the heart of the green UQTR campus, close to all commodities. Trois-Rivieres is a small, family-friendly city where the cost of living is very reasonable.
For these PhD scholarships, candidates are expected to demonstrate a genuine interest in the fundamental mechanisms regulating stem cell proliferation, to be hard-working and dedicated, and to take every action to ensure that the project moves forward.
- A Master’s degree in the Life Sciences with written thesis (except when applying for a MSc).
- Proven experience in basic cell and molecular laboratory techniques.
- Good spoken and written communication in French or English.
- Experience with C. elegans, CRISPR/Cas9, Gibson assembly, cloning techniques, bioinformatics and/or microscopy are not essential, but will be considered an asset.
Salary and appointment terms
Stipends will correspond to the national guidelines (NSERC); 21 000 CAD/year at the PhD level.
The University of Quebec at Trois-Rivieres is an equal opportunity employer and welcomes applications form everyone.
Please send your application by email, in French or English, to Dr Patrick Narbonne (firstname.lastname@example.org), including all documents (cover letter, CV, contact details, thesis and .pdf of refereed publications – if any). Please also ask for three referees to send a letter of recommendation to the above email address, mentioning your name in the subject line. Review of applications will begin on July 1st, 2019.
Only those selected for an interview will be contacted.