University of Freiburg (Uni Freiburg)

Epigenetic control of cancer stem cell biology

University of Freiburg (Uni Freiburg)

Freiburg, Baden-Württemberg, Germany

The fully funded postdoctoral position is available at the Center for Clinical Research, Medical Center, University of Freiburg, Germany. The group led by Prof. Roland Schüle is a multi-disciplinary team with a focus on all aspects of epigenetic regulation including stemness, metabolism, signaling, drug development, and chromatin states. The research group is embedded in the Collaborative Research Centre 992 Medical Epigenetics, a research effort of 20 PIs on various aspects of medical epigenetics, which is headed by Prof. Schüle.

The Schüle lab combines structural analyses and single cell -omics techniques with in vivo approaches such as genetically modified mouse and 3D organoid models to study cancer stem cell biology. The aim is to connect basic research and medical epigenetics with comprehension of human diseases.

 

The proposed project aims to investigate the functions of the novel histone methyltransferase KMT9 (Metzger et al. Nat. Struc. Mol. Biol. 2019) in regulating cancer stem cell function in prostate, bladder, and colon cancer. The overall mission of our team is to unravel the molecular underpinnings of epigenetic regulators such as histone methyltransferases in stemness, growth and tumorigenesis. You will be part of a team, which combines genome-wide analyses, proteomics, metabolomics, and molecular- and cellular biology with crystal structure analysis and medicinal chemistry to identify novel path for translation in clinical practice. In particular, we intersect biology with structural information and medicinal chemistry to develop chemical probes. We offer a dynamic, highly interactive environment and an international working atmosphere with state of the art facilities.

 

Please submit your application in English as a single PDF file to sabine.kandzia@uniklinik-freiburg.de. The application should consist of an up to date CV, a supporting statement, which describes why you would be a suitable candidate for the position, and at least two letters of recommendation.


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Epigenetic control of cancer stem cell biology