Epigenetic control by the novel histone methyltransferase KMT9
(Metzger et al., Nat. Struc. Mol. Biol. 2019)
The fully funded postdoctoral position is available at the Center for Clinical Research, Medical Center, University of Freiburg, Germany. The group led by Prof. Roland Schüle is a multi-disciplinary team with a focus on all aspects of epigenetic regulation including stemness, metabolism, signaling, drug development, and chromatin states. The research group is embedded in the Collaborative Research Centre 992 Medical Epigenetics, a research effort of 20 PIs on various aspects of medical epigenetics, which is headed by Prof. Schüle.
The Schüle lab combines molecular and structural analyses in vitro with in vivo approaches such as genetically modified mouse and 3D organoid models. The aim is to connect basic research and medical epigenetics with comprehension of human diseases. We offer a dynamic, highly interactive environment and an international working atmosphere with state of the art facilities.
The proposed project aims to investigate the physiological and pathological functions of novel histone methyltransferases such as KMT9. We plan to unravel the molecular underpinnings of these histone methyltransferases in stemness, growth and tumorigenesis. We intersect this knowledge with structural information and medicinal chemistry to develop chemical probes. You will be part of a team, which combines genome-wide analyses, proteomics, metabolomics, and molecular- and cellular biology with crystal structure analysis and medicinal chemistry to identify novel path for translation in clinical practice
Please submit your application in English as a single PDF file to firstname.lastname@example.org. The application should consist of an up to date CV, a supporting statement, which describes why you would be a suitable candidate for the position, and at least one reference.