Concordia University

Engineering T-cells using microfluidics

Concordia University

Montreal, Quebec, Canada

Fellowship Description

Research program title

Engineering T-cells using microfluidics

Reference number

7013

Supervisor

Steve Shih

Program description

Preliminary clinical trials harnessing the immune system of cancer patients to combat disease have shown to have impressive efficacy. Immune cells isolated from a patient are genetically altered to allow for improved detection of cancerous cells and subsequently re-introduced into the patient. Yet despite its promise, rapid and cost-effective manufacturing of this therapy remains a barrier to widespread adoption. The goal of this project is to implement a lab-on-a-chip approach to rapidly engineer CAR-T cells for cancer therapies. To achieve this goal, this work will be divided into three aims: 1) Design a microfluidic platform to deliver chimeric antigen receptors into model T-cells (see publication for preliminary work of gene-editing), 2) Activate and expansion of T-cells that are successfully transfected with CAR. 3) Perform the same protocols for primary and stem cells in collaboration with clinicians at St. Justine. If successful, this chip will allow for automated liquid handling and optimization of experimental conditions specific to the genetic engineering of T cells.

Academic qualifications required

PhD in Bioengineering or Electrical Engineering, experience in microfluidics and fabrication and synthetic biology an asset.

Eligibility requirements

  • Applicants must not currently hold a postdoctoral appointment at Concordia
  • Priority will be given to postdoctoral fellows who have obtained their PhD from another university although in exceptional cases Concordia graduates may be considered
  • Applicants must adhere to the postdoctoral fellow eligibility criteria outlined in Concordia University’s Postdoctoral Policy

Timeline and application process

The Postdoctoral Fellow must start his/her appointment by August 31, 2020.

Submission process

  • All documents must be submitted to Niyusha Samadi.
  • Please include the reference number with your application

Application checklist

  • One to three (1-3) page research statement demonstrating fit with the program described above.
  • Current curriculum vitae demonstrating research excellence and a capacity for leadership in the domain (maximum 5 pages).
  • Two letters of reference from academic supervisors or current employers to be sent via e-mail directly to Niyusha Samadi.

Value

The prestigious Horizon Postdoctoral Fellowships are valued at $47,500 per year plus benefits and full access to Concordia’s services, including GradProSkills.

Concordia University is a vibrant research and teaching environment, with state-of-the-art research facilities and many research centers. Concordia is located in Montreal, Canada, a diverse and creative city, often ranked as offering one of the best quality of living experiences in North America.

 

Apply with CV and Cover Letter

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Position

Engineering T-cells using microfluidics