Doctoral student in Medical Science – Molecular biology
Project title: Quality control of mitochondrially encoded proteins during cellular stress
Mitochondria convert chemical energy into ATP by utilizing a system of molecular machines, the respiratory chain complexes. The complexes driving oxidative phosphorylation are a mosaic of proteins encoded by the nuclear and the mitochondrial DNA. Therefore, assembly of the respiratory chain and the ATPase requires not only expression and import of many nuclear encoded proteins but also translation of mitochondrially encoded proteins. It is therefore surprising that so little is known about mitochondrial protein synthesis. The main goal of this project is to unravel how protein synthesis by mitochondrial ribosomes is connected to quality control and proteolysis. Specifically, we will identify how auxiliary factors interact with the mitochondrial ribosome to control the quality of the newly synthesized protein, and if needed, direct the proteins for degradation. Because the respiratory chain is crucial for cellular energy metabolism, defects of mitochondrial gene expression result in severe human diseases. Hence, the information emerging from this study will be relevant for basic as well as for medical sciences. The group employs a large variety of methods ranging from protein biochemistry and molecular biology, genetics in yeast and mammalian cells to high-resolution single particle cryo-electron microscopy. For more information see our homepage: www.martinottlab.com
We are looking for a student who is genuinely interested in basic molecular mechanisms. You should have experience of protein analyzes and / or good knowledge in molecular biology, biochemistry, or cell biology. We value personal integrity as well as interest and commitment to personal development. You should have a good ability to express yourself in English, as the projects are run in an international environment. You should also be able to work both independently and in a group.
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Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell biology.
Extent: 100%, fully funded.
First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.
For more information about the project please contact the principal supervisor, Martin Ott, Professor, Institute of Biomedicine, phone: +46-0722612871, e-mail: firstname.lastname@example.org
Please apply for this position via the University of Gothenburg’s recruitment portal:
You must include the following, in pdf format:
- Letter of motivation
- Diploma and transcripts showing that you meet the general entry requirements
- Proof of completion of English B or the acquired equivalent knowledge through previous studies
Applications must be received by: 2022-10-20