The University of Luxembourg is a multilingual, international research University.
The University of Luxembourg has the following vacancy at the Luxembourg Centre for Systems Biomedicine (LCSB) as part of the H2020 MSCA Interdisciplinary Training Network for advancing Organ-on-a-chip technology in Europe (EUROoC).
Doctoral candidate (Ph.D. student) in the field of organ-on-chip models (m/f)
Area: Integration of iPSC-derived epithelial cells and of on-chip TEER measurement in the HuMiX gut model
Studying how microbial and host cells co-exist and interact in close proximity in the human gut is crucial to further our understanding of how changes in the microbial composition and/or function affect human health in the gut and beyond. Organ-on-chip (OoC) models are a great way to perform such studies. Furthermore, personalized OoC models – using individual-derived cells – are more representative than generic cell line-based models or animal models.
The PhD student will further develop the Human Microbial Crosstalk (HuMiX) gut-on-a-chip system which enables proximal co-culture of microbial cells, epithelial cells, and other mammalian cells, e.g., immune cells.
1. to establish protocols for obtaining iPSC-based intestinal epithelial cell cultures;
2. to integrate iPSC-based intestinal epithelial cell cultures in HuMiX;
3. to conceptualise, design, and fabricate an on-chip TEER measurement system.
Secondments are planned as follows:
- Uppsala Universitet, Sweden for 2 months;
- Universitaetsklinikum Jena, Germany for 3 months;
- Transgene SA, France for 2 months.
For further information, please contact:
Prof. Dr Paul Wilmes
Telephone: +352 46 66 44 6188
- Early-stage researcher: a researcher without a PhD, who is in the first four years (full-time equivalent research experience) of her/his research career, measured from the date when she/he obtained the degree, which would formally entitle her/him to embark on a doctorate.
- Graduation in the field of biology, biomedical engineering or related fields – M.Sc. required.
- Basic knowledge of microfabrication, biomechanics, 3D cell models and/or cell culture.
- Practical experience of stem cell culture & differentiation and fluorescence microscopy is a plus.
- Basic knowledge of data analysis and Microsoft Office.
- Well-structured and autonomous working style, good organizational and communication skills.
- Fluency in written and spoken English is a must, German and/or French is a plus.
The applicant must not have resided or carried out her/his main activity (work, studies etc.) in Luxembourg for more than 12 months in the past three years.
- Fully funded PhD position by the Marie Skłodowska-Curie European Training Network „EUROoC“ (H2020-MSCA-ITN-2018) – More information on the ITN at https://www.eurooc.eu.
- The opportunity to work as part of an international, interdisciplinary team of 15 PhD students, based at universities and industrial firms throughout Europe. She/he will gain a unique skill-set comprising microfabrication, biomaterial science and stem cell differentiation, as well as an overview of different organ-on-a-chip technologies and their implementation at industrial level
- The University offers competitive salaries and is an equal opportunity employer. The monthly salary consists of a living allowance, mobility allowance and family allowance (if applicable)
The Ph.D. student will work in the Eco-Systems Biology group at the LCSB and will be supervised by the head of the group, Prof. Dr. Paul Wilmes.
Applications (in English) should contain the following documents:
- A detailed curriculum vitae
- Letter of motivation (up to 2 pages) which states your research experience and interests and which mentions the application’s reference number
- A half-page summary of master/diploma thesis
- Names and contact information of at least two academic referees who could write a letter of recommendation by e-mail
Please apply ONLINE until 15.09.2019.
The University of Luxembourg is an equal opportunity employer.
Link : http://emea3.mrted.ly/2917w