Johnson & Johnson

DMPK Mechanistic Modeling/Assay Development Postdoctoral Researcher

Johnson & Johnson

Spring House, PA, United States

Location: Spring House, Pennsylvania
Function: R&D

Job Description

Requisition ID: 7797190215

Caring for the world, one person at a time has inspired and united the people of Johnson & Johnson for over 130 years. We embrace research and science - bringing innovative ideas, products and services to advance the health and well-being of people.

With $76.5 billion in 2017 sales, Johnson & Johnson is the world’s most comprehensive and broadly-based manufacturer of health care products, as well as a provider of related services, for the consumer, pharmaceutical, and medical devices markets. There are more than 250 Johnson & Johnson operating companies employing over 125,000 people and with products touching the lives of over a billion people every day, throughout the world. If you have the talent and desire to touch the world, Johnson & Johnson has the career opportunities to help make it happen.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

Janssen, a member of Johnson & Johnson’s Family of Companies, is recruiting a PK/PD Modeling and In Vitro Assay Post-doctoral Intern. The internship is offered by the Drug Metabolism and Pharmacokinetics (DMPK) group within the Discovery, Product Development and Supply group of Janssen. The DMPK group supports discovery and development of therapies for a range of indications including oncology, cardiovascular, metabolic, neurological and immunological diseases.

The focus of this internship will be to drive forward the relatively underdeveloped science of intestinal stability and absorption of peptides/peptidomimetic drugs. While many peptides cannot be developed for oral use due to low intestinal absorption rates and high gut instability, exceptions exist (e.g. cyclic peptides). Through mechanistic gut and PBPK modeling of existing data, as well as in vitro/in vivo assay development, the postdoctoral intern will improve our understanding of what drives peptide stability and absorption and how to apply this to drug discovery and development programs.

The Postdoctoral Intern will:

  • Work with PBPK/PK-PD modelers to develop techniques to understand gut tissue exposure and systemic absorption of peptides.
  • Collaborate with in vitro and in vivo scientists to develop assays appropriate for peptides and translatable to the clinic.
  • Collaborate with internal and external experts to leverage knowledge and data from all available sources.

  • Candidates must be enrolled in an accredited college/university pursuing a PhD in mathematical modeling, biology, chemistry, biochemistry or a related discipline, or recently have completed their Ph.D. in these areas (<2 years).
  • Candidates must be available to work Full-time).
  • Candidates must be legally authorized to work in the United States and not require sponsorship for employment visa status (e.g. H1-B status) now or in the future.
  • Demonstrated leadership including publication of high impact, peer-reviewed publications is required.
  • Candidates must be detail-oriented, highly organized and able to manage multiple tasks.
  • Candidates must have the ability to work individually (independently) as well as on a team in a matrix environment.
  • Candidates must be proficient with Microsoft Office, Word, Excel (including a high proficiency with generating pivot tables and graphs), and Power Point, and have strong oral and written communication skills. Additional technical competencies in SharePoint and other information technology systems are highly desirable, as is experience with PubMed databases and other literature databases.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location
United States-Pennsylvania-Spring House
Janssen Research & Development, LLC (6084)
Job Function
Requisition ID


Please apply via recruiter’s website.

Quote Reference: 115248350