Dermal Drug Discovery Principle Scientist at Healx
Start Date: Immediate preferred
Salary: Competitive compensation package including share options, subject to experience
Closing Date: June 15, 2019
Healx is a fast growing Cambridge, UK start-up, combining computational methods and deep drug discovery expertise to identify existing drugs that may treat rare diseases, enabling treatments to be found at a fraction of the time and cost of traditional drug discovery. There are over 7,000 rare diseases that affect an estimated 350 million people worldwide, most of which lack effective treatment. We work closely with patient groups and charities to understand clinical unmet need and with industry to help them find opportunities for progress in rare diseases.
We’re looking for a talented specialist in dermal drug discovery to help build our portfolio of drug repurposing candidates in dermal disease. This is a key role with the opportunity to have a major impact during our next phase of growth.
•Using your dermal disease knowledge, you will help identify rare dermal diseases that are tractable to our drug matching technologies and build a portfolio of multiple drug discovery projects
•Help rank predicted drugs based on evidence of their target biochemical pathways that are relevant to each disease
•Guide project translation through preclinical stages, providing in vitro / in vivo study design input and contract-out testing of the predictions to external CROs or academic laboratories
•Write summary reports including chemical, biochemical, pharmacological, pharmaceutical, pharmacokinetic and medical properties to justify the selection of candidate drugs
•Advise whether patent filing and progression to clinical trials is merited
•Report directly to the CSO and engage with the Pharmacology Advisory Board to refine and finalise drug repurposing predictions
•Work with bioinformaticians and software engineers developing algorithmic methods and tools, provide pharmacology input for new developments
Who we’re looking for
•University Degree (with at least a 2:1) and postgraduate degree from a top university in Biochemistry/ Pharmacology or related discipline
•Minimum of 5 years of experience in dermal drug discovery in a pharmaceutical environment or related
•In depth-knowledge of the drug discovery and drug development process from project start-up to clinical trials and have a track record of progressing drugs through the discovery process
•Able to demonstrate a strong understanding of dermal disease biology applied to drug discovery
•Experience of pre-clinical study design
•Experience in drug repurposing desirable
How to apply
Please submit your CV and Cover letter to apply. Applying by any other means may not be successful.
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