NC3Rs

Deputy Head, Transgenic Core Facility

National University of Singapore (NUS)

Singapore, Singapore

The Transgenic and Gene Targeting Facility is a joint operation between Cancer Science Institute (CSI) and the Comparative Medicine (CM) animal facility at NUS. The Facility operates as a “business” where customer-service and project-management skills are paramount.


The Deputy Head of the Facility is responsible to oversight and to provide day to day management of the Transgenic Core Facility on routine technologies such as embryo rederivation or cryo-conservation (embryo- and sperm freezing) as well as, on established and novel technologies enabling generation of new mouse models, including ES-cell injection, pronucleus injection (transgenic mouse models) and gene-editing via CRISPR/Cas9 (both on ES-cells and via electroporation into embryos).


Duties & Responsibilities

 -       Assist Facility Head in the day to day operations, pricing for services and budgeting of the Facility

-       supervise the specialised and trained technicians, already working there, ensuring effective customer service and project management

-       Keep up to date with the latest technologies and advances relevant to the Facility

-       Responsible for effective marketing, advertising and training to keep abreast of the research needs in order to encourage scientists to use the Facility

-       Oversee all routine and complex breeding of rodent colonies for the Facility

-       Partner with Principal Investigators to establish cohort needs, measuring progress and addressing all issues that arise

-       guide scientists in designing new mouse models 

-       Responsible to maintain adequate number of animals by setting up breeding pairs, manage breeding rotations and setting up timed pregnancies.

-       Responsible for Facility’s weaning and identification of pups, and genotyping of each animal in order to generate homozygous or transgenic lines, and maintaining appropriate breeding schemes per strain

-       Observe rodents for obvious phenotype and perform a natural history analysis when necessary

-       Maintain detailed and accurate records (GLP and non-GLP) for all colonies and perform record audits as needed to ensure accuracy and maintain compliance

-       Perform as well as supervise Facility team in other technical research procedures (dosing, injections, sample collections, etc.) and husbandry activities as needed.

-       Participate in an occupational safety and health programs which may require tuberculin testing and potentially immunization

-       Weekend work, holiday work and overtime hours are a requirement of this position

 -       Any other duties as assigned with respect to Facility needs


Requirements

Applicants should be motivated, team-oriented and open-minded with a PhD in life/biological sciences. In addition, the following qualifications are required:

-      good skills and in-depth hands-on experience in molecular techniques related to cloning and genome editing via CRISPR/Cas9.

-       3 to 5 years of relevant experience working with transgenic animal models or equivalent combination of education and experience required.

-       Must have experience handling rodents and other lab animals

-       Must have experience with rodent breeding programs and have a working knowledge of breeding, weaning, and record-keeping

-       GLP experience preferred

-       Excellent demonstrated accuracy, attention to detail and work ethic is a must!

-       Excellent oral and written communication skills, including demonstrated ability to communicate effectively with all levels of staff

-       Must have a demonstrated ability to foster positive relationships with co-workers and researchers

-       Must have a demonstrated ability to work independently, with minimal supervision.

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Position

Deputy Head, Transgenic Core Facility