Astex Pharmaceuticals Limited

Data Scientist, Bioinformatics (Ref: DS/1219)

Astex Pharmaceuticals Limited

Cambridge, United Kingdom

Job Title: Data Scientist, Bioinformatics (Ref: DS/1219)

Job Type: Permanent

Location: Cambridge, UK

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.



The bioinformatics team at Astex works with multi-disciplinary project teams throughout the discovery, preclinical and clinical pipeline, with a focus on NGS technologies, multi-omics data, functional genomics and structural bioinformatics, to drive new target evaluation, preclinical and clinical research. We are looking for an experienced data scientist to join our bioinformatics team. The position will provide the candidate with an opportunity to apply their computational and mathematical skills to develop innovative methods for analysing complex multi-layered omics data to identify novel targets and biomarkers associated with diseases. We are looking for a candidate with significant experience in data science research, for example in data mining, statistics, mathematical modelling and machine learning.

Principal Responsibilities

  • Developing and implementing novel statistical approaches to analyse diverse multi-layered omics data types (eg. genomics, transcriptomics, proteomics) to identify novel drug targets, biomarkers and therapeutic mechanisms
  • Leading the development of analytical models using statistical, mathematical and machine learning methods for biomarker development and patient stratification strategies
  • Integration and meta-analysis of public & internal data sets to generate testable hypotheses
  • Providing support to the bioinformatics team in applying innovative statistical methods & data integration approaches
  • Staying up-to-date with novel bioinformatics methodologies, tools and applications
  • Maintaining and expanding the team’s knowledge of high-throughput “omics” data sources
  • Contributing to the general development of Astex’s bioinformatics platform and capabilities

Candidate Requirements

  • Degree in a numerical discipline (data science, statistical genetics, applied mathematics, physics, engineering, computer science or similar)
  • Demonstrated working knowledge of statistical methods (eg. Bayesian approaches, probabilistic programming, Gaussian processes, mendelian randomization) and graphical models
  • Knowledge of machine learning methods, for example neural networks, random forests, SVMs, regression, clustering, dimensionality reduction or ensemble methods
  • Programming proficiency with Python, R or similar
  • Experience in developing algorithms and workflows
  • Good understanding of NGS techniques, cancer genomics and analytical approaches for analysing multi-omics and multimodal data sets is desirable
  • Excellent written and oral communication skills, including an ability to communicate with computational and experimental scientists

We offer excellent training and career development opportunities as well as competitive salary and benefits package.

To apply please send your CV and a cover letter, quoting the job reference: DS/1219 to

Closing Date: 31st January 2020

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Data Scientist, Bioinformatics (Ref: DS/1219)