Computational Postdoctoral Research Scientist
Single cell transcriptomics of cellular models for inflammatory bowel diseases.
We are looking for a computational postdoctoral fellow to drive a collaborative project between Dr Gosia Trynka group at Wellcome Sanger Institute and Prof Matthias Zilbauer at the University of Cambridge.
PROJECT: This research project aims at investigating the role of transcriptional mechanisms in regulating human intestinal epithelial cell function in health and inflammatory bowel diseases (IBD). The project will use established access to a large patient cohort providing human intestinal tissue for the generation of organoids and single cell transcriptomics for profiling. You will integrate this data with results from CRISPR-screens to identify pathways relevant for prioritisation of new drug targets for IBD.
ENVIRONMENT: We are an interdisciplinary team of experimentalists, clinical and industry collaborators. This is an excellent opportunity to be engaged in all aspects of a large-scale project, from planning and data generation through to analysis and novel discovery. Our goal is to accelerate drug discovery by integrating disease GWAS variants with single cell transcriptomics data generated in this project to identify the most promising therapeutic targets for follow up. This project forms part of the Open Targets collaboration and provides a great opportunity to deliver real translational solutions working at the Wellcome Sanger Institute, in close collaboration with the Zilbauer group at Addenbrookes Hospital and with industry partners including Takeda, GSK, Celgene, and Sanofi.
TEAM WORK: The post-holder will join a diverse, supportive and friendly team of scientists, clinicians and other professionals. We place major emphasis on the importance of team work and an enjoyable work environment as a foundation for performing internationally leading translational research.
CANDIDATE: The most important selection criteria are evidence of academic excellence, personal drive and a clear rational for joining our group. The post requires someone who is enthusiastic, focused, and has a passion for cutting edge translational science.
• PhD in a relevant subject area (e.g. Biology, Genetics, Computational Biology, Statistics)
• Ability to communicate effectively with interdisciplinary team members and collaborators
• Ability to work both independently and as part of a team
• Ability to work with others in a friendly and collegiate environment
• Demonstrable high level of communication skills both written and oral
• A passion for problem solving and creative thinking
• Excellent organisational skills
• Experience in the analysis of functional genomic datasets (e.g. gene expression datasets)
• Proficiency in a scripting language (e.g. R, Python, Perl)
Open Targets (https://www.opentargets.org/) is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.
Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.
The Zilbauer group is located at the Addenbrookes Hospital is in the heart of the Cambridge Biomedical Research Campus (http://cambridge-biomedical.com) with access to state-of-the-art research facilities. In addition we benefit from strong established collaborations particularly to the Cambridge Stem Cell Institute (http://www.stemcells.cam.ac.uk) and the Wellcome Sanger Institute (https://www.sanger.ac.uk).
Please include a CV and a cover letter describing your skills with your application.
Closing date: 02 April 2020
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog.
Set across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world’s foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges.
There’s an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site
Being part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events
Find out more about our Genome Wellcome Campus.
We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.